Results 31 to 40 of about 107,498 (247)

Inflammatory landscape in Xeroderma pigmentosum patients with cutaneous melanoma

Scientific Reports, 2022
Xeroderma pigmentosum (XP) is a DNA repair disease that predisposes to early skin cancers as cutaneous melanoma. Melanoma microenvironment contains inflammatory mediators, which would be interesting biomarkers for the prognosis or for the identification ...
Asma Chikhaoui, Meriem Jones, Tadeja Režen, Melika Ben Ahmed, Chokri Naouali, Radovan Komel, Mohamed Zghal, Samir Boubaker, Sonia Abdelhak, Houda Yacoub-Youssef   +9 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

O impacto da tecnologia blockchain nos negócios e suas aplicações

Cadernos Cajuína
A pesquisa teve o objetivo de discutir de forma reflexiva sobre o impacto do Blockchain nos negócios e suas aplicações, evidenciando que o impacto da tecnologia blockchain nos negócios é indiscutível.
Ivaneide Pereira Cardoso Maués, Angélica Portela da Ponte Dias, Alriberto Dourado Ferreira, Elser Fernando Provin, Jefferson de Abreu Monteiro, Lucas Campos de Magalhães Nunes, Pedro Antonio Ferreira, Silvana Maria Aparecida Viana Santos   +7 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Low‐Angle Grain Boundaries and Re‐Segregation in Single‐Crystalline Ni‐Base Superalloys

Advanced Engineering Materials, EarlyView.
This work demonstrates that Re‐segregation at low‐angle grain boundaries (LAGBs) in Ni‐base superalloys is influenced by misorientation angle. Advanced microscopy and atom probe tomography reveal that higher misorientation angles increases Re‐segregation.
Alireza B. Parsa, Aparna Saksena, Alesander Kostka, Pascal Thome, Felicitas Scholz, Alexandre Mussi, Christoph Somsen, Baptiste Gault, Jan Frenzel, Gunther Eggeler   +9 more
wiley   +1 more source

Proinflammatory cytokines in xeroderma pigmentosum (XP) and non-XP cancer patients—a pilot study

Exploration of Immunology
Aim: Testing the feasibility of the determination to what extent the inability to repair DNA lesions in xeroderma pigmentosum (XP) patients, contributes to the alteration of immune responses, in the course of skin carcinogenesis.
Kalthoum Abid, Jihene Bettaieb, Faouzi El Mezni, Hamouda Boussen   +3 more
doaj   +1 more source

Early-onset gynecological tumors in DNA repair-deficient xeroderma pigmentosum group C patients: a case series

Communications Medicine, 2023
Background Xeroderma pigmentosum (XP) is a group of rare hereditary disorders with highly increased risk of skin tumors due to defective DNA repair. Recently we reported 34-fold increased risk of internal tumors in XP patients in comparison with general ...
Andrey. A. Yurchenko, Brice Fresneau, Bruno Borghese, Fatemeh Rajabi, Zora Tata, Catherine Genestie, Alain Sarasin, Sergey I. Nikolaev   +7 more
doaj   +1 more source

Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients

Frontiers in Oncology, 2022
Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers.
Mahlatse C. M. Kgokolo, Katherine Anderson, Shalate C. Siwele, Helen C. Steel, Luyanda L. I. Kwofie, Luyanda L. I. Kwofie, Mike M. Sathekge, Pieter W. A. Meyer, Pieter W. A. Meyer, Bernardo L. Rapoport, Bernardo L. Rapoport, Ronald Anderson   +11 more
doaj   +1 more source

XPS Investigation of a CdS-Based Photoresistor under Working Conditions: Operando–XPS [PDF]

Analytical Chemistry, 2012
A noncontact chemical and electrical measurement X-ray photoelectron spectroscopy (XPS) technique is performed to investigate a CdS-based photoresistor during its operation. The main objective of the technique is to trace chemical- and location-specified surface potential variations as shifts of the XPS Cd 3d(5/2) peak position without and under ...
Sezen, H., Rockett, A. A., Suzer, S.
openaire   +6 more sources

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source