Results 71 to 80 of about 1,113 (188)

Xuebijing Protects Against Septic Acute Liver Injury Based on Regulation of GSK-3β Pathway

Frontiers in Pharmacology, 2021
Xuebijing (XBJ), the only drug approved for the sepsis and multiple organ dysfunction, and its protective effects against acute liver injury (ALI) and its mechanism. The aim of this study was to evaluate the protective effect of XBJ on cecal ligation and
Liping Cao, Liping Cao, Zhenghong Li, Yi Ren, Mengmeng Wang, Zhizhou Yang, Wei Zhang, Xiaoqin Han, Mengya Yao, Zhaorui Sun, Shinan Nie   +10 more
doaj   +1 more source

Antiviral effects and mechanism of Qi pi pill against influenza viruses

Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1364-1375, August 2025.
Qi pi pill presents anti‐influenza effect and inhibits viral replication in vitro by targeting both the viral RNA replication and the release of new viral particles. Furthermore, QPP modulates the production of proinflammatory cytokines induced by influenza infection in host cells.
Chengcheng Zhang, Jing Gao, Meiyue Dong, Carolina Q. Sacramento, Ping Li, Xiangyu Lian, Lingyuan Fan, Lijun Rong, Ruikun Du, Jingzhen Tian, Qinghua Cui   +10 more
wiley   +1 more source

Effect of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma

, 2010
ObjectiveTo investigate the effect and clinical significance of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma.MethodsThirty-three patients with severe trauma were randomly divided into a control group (n=16)
LU, Yuan-qiang, HUANG, Wei-dong, GU, Lin-hui   +2 more
core   +1 more source

A Subgroup Reanalysis of the Efficacy of Bufei Huoxue Capsules in Patients With “Long‐Covid‐19”

Pulmonary Circulation, Volume 15, Issue 2, April 2025.
ABSTRACT Bufei huoxue capsules (BFHX), manufactured products of traditional Chinese medicine, have demonstrated anti‐inflammatory properties and efficacy against chronic pulmonary diseases and COVID‐19. This study was designed to further determine the clinical efficacy of BFHX in diverse patient subgroups during the convalescent phase of COVID‐19 ...
Chi Hou, Yue Xing, Yuqin Chen, Tingping Wang, Jingjing Qi, Xiaoqing Jia, Xiansheng Zeng, Jianling Bai, Wenju Lu, Yu Deng, Bihua Zhong, Yongxia Lei, Yilin Chen, Zhan Lian, Haohao Zhou, Junping Yan, Xuejiao Yang, Hao Yu, Jiawei Zhou, Lixia Qiu, Yunliang Zhai, Wanli Geng, Nanshan Zhong, Chunli Liu, Jian Wang   +24 more
wiley   +1 more source

Comprehensive characterization of Xuebijing injection and comparative analysis of its systemic exposure in patients with severe pneumonia, sepsis, and acute pancreatitis

Journal of Chromatography Open
This study aimed to investigate the chemical constituents of Xuebijing injection and compare differences in its systemic exposure components among patients with severe pneumonia, sepsis, and acute pancreatitis during the steady-state blood concentration ...
Mingxin Guo, Shuo Chen, Xia Wu, Zhiqiang Hu, Yanchun Chen, Baohu Jiang   +5 more
doaj   +1 more source

Metabolomic Insights Into the Synergistic Effect of Biapenem in Combination With Xuebijing Injection Against Sepsis

Frontiers in Pharmacology, 2020
The drug combination of biapenem (BIPM) and xuebijing injection (XBJ) is commonly applied for the treatment of sepsis in China. However, the potential synergistic mechanism is still enigmatic.
Li-Wei Liu, Li-Wei Liu, Li-Wei Liu, Ying-Ying Shi, Ying-Ying Shi, Ying-Ying Shi, Zhuo-Lun Li, Zhuo-Lun Li, Zhuo-Lun Li, Li-Hua Zuo, Li-Hua Zuo, Li-Hua Zuo, Meng Tang, Zi-Wei Jing, Zi-Wei Jing, Zi-Wei Jing, Hong-Yu Zhao, Peng Xue, Lin Zhou, Lin Zhou, Lin Zhou, Qiu-Zheng Du, Qiu-Zheng Du, Qiu-Zheng Du, Xiao-Jian Zhang, Xiao-Jian Zhang, Xiao-Jian Zhang, Zhi Sun, Zhi Sun, Zhi Sun   +29 more
doaj   +1 more source

Sepsis: the evolution of molecular pathogenesis concepts and clinical management

MedComm, Volume 6, Issue 3, March 2025.
(A) The innate and adaptive immune responses established during long‐term evolution can eliminate most invading microorganisms. (B) Sepsis only occurs when the balance is disrupted and the pathogen force overwhelms the host's defense force. (C) Only when the superposition of external forces (sensitive antimicrobial drugs) and internal forces ...
Zhongxue Feng, Lijun Wang, Jing Yang, Tingting Li, Xuelian Liao, Yan Kang, Fei Xiao, Wei Zhang   +7 more
wiley   +1 more source

Protective effects of Dioscin against sepsis‐induced cardiomyopathy via regulation of toll‐like receptor 4/MyD88/p65 signal pathway

Immunity, Inflammation and Disease, Volume 12, Issue 5, May 2024.
(1) Dioscin improved the myocardial tissue damage of SIC rat. (2) Dioscin improved LPS‐decreased the activities of SOD, CAT, and GSH. (3) Overexpressed TLR4 promoted the Dioscin‐suppressed the viability of H9c2 cell. Abstract Background Dioscin has many pharmacological effects; however, its role in sepsis‐induced cardiomyopathy (SIC) is unknown ...
Meng Zhang, Deyuan Zhi, Pei Liu, Yajun Wang, Meili Duan   +4 more
wiley   +1 more source

Xuebijing and somatostatin against acute pancreatitis: A systematic review and network pharmacology. [PDF]

Medicine (Baltimore)
Background: Acute pancreatitis (AP) is a common pancreatic disease. Xuebijing injection (XBJ) combined with somatostatin in the treatment of AP is frequently used in clinical practice. There is, however, a lack of high-quality evidence-based evidence and network pharmacology to regard the therapeutic efficacy and ...
Cao JP, Piao XH, Zhu LX, Feng PF.
europepmc   +3 more sources

Plant‐derived compounds as potential leads for new drug development targeting COVID‐19

Phytotherapy Research, Volume 38, Issue 3, Page 1522-1554, March 2024.
Abstract COVID‐19, which was first identified in 2019 in Wuhan, China, is a respiratory illness caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Although some patients infected with COVID‐19 can remain asymptomatic, most experience a range of symptoms that can be mild to severe. Common symptoms include fever, cough,
Lingxiu Liu, Maxim Kapralov, Mark Ashton
wiley   +1 more source