Results 51 to 60 of about 56,903 (162)

Reinforcement Learning for Jump‐Diffusions, With Financial Applications

Mathematical Finance, EarlyView.
ABSTRACT We study continuous‐time reinforcement learning (RL) for stochastic control in which system dynamics are governed by jump‐diffusion processes. We formulate an entropy‐regularized exploratory control problem with stochastic policies to capture the exploration–exploitation balance essential for RL.
Xuefeng Gao, Lingfei Li, Xun Yu Zhou
wiley   +1 more source

The influence of psychosocial and sexual wellbeing on quality of life in women with differences of sexual development

Comprehensive Psychoneuroendocrinology, 2021
Background: Previous research indicating that women with differences of sexual development (DSD), namely women with Turner syndrome (TS), women with congenital adrenal hyperplasia (CAH), and women with XY-DSD, have an impaired psychosocial and sexual ...
Ariane Liedmeier, David Jendryczko, Marion Rapp, Robert Roehle, Ute Thyen, Baudewijntje P.C. Kreukels   +5 more
doaj   +1 more source

Monolithic Framework to Simulate Fluid‐Structure Interaction Problems Using Geometric Volume‐of‐Fluid Method

International Journal for Numerical Methods in Fluids, Volume 98, Issue 10, Page 1105-1125, October 2026.
A three‐dimensional fluid‐structure interaction (FSI) framework is developed using the geometric volume‐of‐fluid (VOF) interface capturing method and applied to assess largescale turbulent FSI interactions. The monolithic FSI framework is extensively validated, and despite the discontinuities across the interface, the FSI framework delivers stable and ...
Soham Prajapati, Ali Fakhreddine, Krishnan Mahesh   +2 more
wiley   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Clinical and molecular spectrum of 46,XY disorders of sex development that harbour MAMLD1 variations: case series and review of literature

Orphanet Journal of Rare Diseases, 2020
Background Mastermind-like domain-containing 1 (MAMLD1) has previously been identified as a causative gene for “46,XY Disorders of Sex Development (DSD)”. Recently, there has been some controversy regarding the causative role of MAMLD1 variations in DSDs.
Lele Li, Chang Su, Lijun Fan, Fenqi Gao, Xuejun Liang, Chunxiu Gong   +5 more
doaj   +1 more source

Monogenic forms of DSD: An update

, 2021
International audienceDSD encompasses a wide range of pathologies that impact gonad formation, development and function in both 46,XX and 46,XY individuals.
Kenneth McElreavey, Anu Bashamboo, Mcelreavey, Ken, Bashamboo, Anu   +3 more
core   +1 more source

Steroidogenic factor-1 (SF-1) gene mutation as a frequent cause of primary amenorrhea in 46,XY female adolescents with low testosterone concentration

Reproductive Biology and Endocrinology, 2010
Background Primary amenorrhea due to 46,XY disorders of sex differentiation (DSD) is a frequent reason for consultation in endocrine and gynecology clinics.
Servant Nadège, Raingeard Isabelle, Lespinasse James, Frances Anne-Marie, Polak Michel, Thibaud Elisabeth, Zenaty Delphine, Leprieur Elodie, Philibert Pascal, Audran Françoise, Paris Françoise, Sultan Charles   +11 more
doaj   +1 more source

Gender Identity and Assignment Recommendations in Disorders of Sex Development Patients: 20 Years’ Experience and Challenges

JCRPE, 2020
Objective:Gender assignment in infants and children with disorders of sex development (DSD) is a stressful situation for both patient/families and medical professionals.Methods:The purpose of this study was to investigate the results of gender assignment
Fatih Gürbüz, Murat Alkan, Gonca Çelik, Atıl Bişgin, Necmi Çekin, İlker Ünal, Ali Kemal Topaloğlu, Ünal Zorludemir, Ayşe Avcı, Bilgin Yüksel   +9 more
doaj   +1 more source

Reproducibility of Serum Androgen Concentrations by Liquid Chromatography Mass Spectrometry in Healthy Male and Female Athletes

Drug Testing and Analysis, Volume 18, Issue 9, Page 1220-1224, September 2026.
Box and whiskers plots show the distributions of serum testosterone (T), dihydrotestosterone (DHT), androstenedione (A4), and the ratios of T/FDHT and T/A4. ABSTRACT Detection of androgen doping relies on mass spectrometry‐based methods to detect natural endogenous and exogenous androgens in urine and serum. To distinguish exogenous administration from
D. J. Handelsman, S. Bermon
wiley   +1 more source

Modern competency‐based teaching of human sexual development

Anatomical Sciences Education, Volume 19, Issue 7, Page 1086-1096, July 2026.
Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler, Alessandro Bilella, Christian M. Hammer   +2 more
wiley   +1 more source