Results 301 to 310 of about 317,266 (398)
Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han+24 more
wiley +1 more source
snPATHO-seq: A Detailed Protocol for Single Nucleus RNA Sequencing From FFPE. [PDF]
Arjumand W+4 more
europepmc +1 more source
Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu+22 more
wiley +1 more source
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun+14 more
wiley +1 more source
Influence of Aluminum Incorporation on the Adsorptive Performance of Silica-Based Supported Sulfonic Acid for the Chemical Recovery of Gaseous <i>O</i>-Xylene. [PDF]
Wang Y, Chai J, Li Y, Ma Z.
europepmc +1 more source
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou+15 more
wiley +1 more source
{α,α'-Bis[(<i>tert</i>-but-yl)(6-meth-oxy-pyridin-2-yl)phosphino]-<i>o</i>-xylene}(η<sup>2</sup>-<i>N</i>-methyl-maleinimide)palladium(0) toluene hemisolvate. [PDF]
Müller S+4 more
europepmc +1 more source
This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein+9 more
wiley +1 more source