Results 131 to 140 of about 11,512 (298)

Exposure to benzene, toluene and xylenes (BTX) and biological aging: epidemiological evidence from Chinese industrial workers and mechanistic insights

Environment International
Benzene, toluene and xylenes (BTX) are common workplace volatile organic compounds, but evidence linking BTX exposure to biological aging is limited. We examined associations between urinary BTX metabolites and biological age acceleration, and explored ...
Bin Yang, Xiangkai Zhao, Mengqing Yan, Yangyang Jia, Zhiguang Gu, Xiaoyu Hao, Sihua Wang, Zhiheng Li, Xiangwei Zhao, Yongli Yang, Pengpeng Wang, Wei Wang   +11 more
doaj   +1 more source

Reaction of xylenes with tert.-butylchloride in presence of anhydrous aluminium chloride

, 2008
371-373Reactions of ortho- and meta-xylenes with tert.-butyl chloride in presence of anhydrous AlCl₃ as catalyst have been studied. Effects of variation of temperature, molar ratio of xylene to tert.-butyl chloride, amount of catalyst and reaction time ...
Ismail, Mohammad, Saha, Manoranjan, Sharif, Nashid, Siddiky, Md Noor Alam, Alam, Mohammad Zahangir   +4 more
core  

Friedel–Crafts green alkylation of xylenes with tert-butanol over mesoporous superacid UDCaT-5

, 2012
Friedel–Crafts green alkylation of xylenes with tert-butanol was investigated in the presence of mesoporous superacidic catalysts named as UDCaT-4, UDCaT-5 and UDCaT-6.
Kamble, Shashikant B., Shashikant B. Kamble, Yadav, Ganapati D., Ganapati D. Yadav   +3 more
core   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Lifetime Cancer Risk and Hazard Quotient of BTXs Compounds in Iranian Petrochemical and Petroleum Depot Workers

Iranian Journal of Health, Safety and Environment, 2018
Exposing to the high-level of BTXs concentration can occur in the oil-dependent industries and may cause considerable adverse impacts on the health of employees. The main objective of the present study firstly is determining the exposure of petrochemical
Razzagh Rahimpour, Sajjad Farhadi, Mahdi Jalali   +2 more
doaj  

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Crystal engineering of a rectangular sql coordination network to enable xylenes selectivity over ethylbenzene†

, 2020
Separation of the C8 aromatic isomers, p-xylene (PX), m-xylene (MX), o-xylene (OX) and ethylbenzene (EB), is relevant thanks to their widespread application as chemical feedstocks but challenging because of their similar boiling points and close ...
Daniel O'Nolan (12578758), Amrit Kumar (3236604), Michael J. Zaworotko (1298718), Mei-Hui Yu (3355967), Naveen Kumar (12351595), Shi-Qiang Wang (205491), Andrey A. Bezrukov (4501159), Ewa Patyk-Kaźmierczak (12584950), Xian-He Bu (1605673), Soumya Mukherjee (1406128), Ze Chang (1744105)   +10 more
core  

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source