Results 151 to 160 of about 66,759 (345)

Deconvolution of gas chromatographic data [PDF]

The use of deconvolution methods on gas chromatographic data to obtain an accurate determination of the relative amounts of each material present by mathematically separating the merged peaks is discussed. Data were obtained on a gas chromatograph with a
Howard, S., Rayborn, G. H.
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Application of In Situ Fiberization for fabrication of improved strain isolation pads and graphite epoxy composites [PDF]

The feasibility of applying the in situ fiberization process to the fabrication of strain isolation pads (SIP) for the Space Shuttle and to the fabrication of graphite-epoxy composites was evaluated.
Basiulis, D. I., Rosser, R. W., Seibold, R. W.   +2 more
core   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Associations between ambient exposure to styrene, benzene, toluene, ethylbenzene, and xylenes and hospitalizations in the US Gulf region. [PDF]

Environ Res
Choi Y, Wang CT, Warren JL, Woo JH, Engel LS, Baek BH, Bell ML.   +6 more
europepmc   +1 more source

Sugarcane bagasse ex-situ catalytic fast pyrolysis for the production of Benzene, Toluene and Xylenes (BTX)

, 2018
P. Ghorbannezhad, M. D. Firouzabadi, A. Ghasemian, P. Wild, H. J. Heeres   +4 more
semanticscholar   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Breathing-Zone Exposure to Aromatic Volatile Organic Compounds in Surgical Smoke During Transurethral Resection of Bladder Tumor: A Prospective Paired Monitoring Study. [PDF]

Toxics
Jo SB, Ahn ST, Oh MM, Shim SH, Ahn CM, Oh SG, Kim JW.   +6 more
europepmc   +1 more source