Results 191 to 200 of about 9,070 (259)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Impact of environmental exposures on exhaled breath and lung function: NELA Birth Cohort. [PDF]

ERJ Open Res
Sola-Martínez RA, Jiménez-Guerrero P, Sánchez-Solís M, Lozano-Terol G, Gallego-Jara J, Martínez-Vivancos A, Morales E, García-Marcos L, de Diego Puente T, NELA Study Group.   +9 more
europepmc   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Catalyst Influence on the Crystallization Behaviors and Mechanical Properties of Polyethylene Vitrimers. [PDF]

Macromolecules
Valdez S, Qiang Z.
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Toxicological Response of the BEAS-2B Cell After Acute Exposure at the Air-Liquid Interface to Ethylbenzene and m-Xylene Alone and in Binary Mixtures. [PDF]

J Appl Toxicol
Jaber N, Emond C, Cazier F, Billet S.
europepmc   +1 more source

Arene Insertion Reactivity of α‑Diimine-Supported Cobalt(I) Hydrides. [PDF]

Organometallics
Moffa KL, Palmer WN, Pecoraro MV, Pappas I, Bezdek MJ, Chirik PJ.   +5 more
europepmc   +1 more source

An analysis of working dog exposure to environmental contaminants at the Surfside building collapse. [PDF]

Front Vet Sci
Perry EB, Karpinsky M, Bender K, Liang S, Jenkins EK, Discepolo D, Marquart ET, DeGreeff L.   +7 more
europepmc   +1 more source

Cu-catalyzed oxidative coupling of alkylarenes with tertiary C(sp³)-H bonds <i>via</i> C-H activation.

Org Biomol Chem
Hong G, Nahide PD, Patel WG, Kozlowski MC.   +3 more
europepmc   +1 more source

Through-Space Stabilization of Carbon-Centered Aryl Dicyanomethyl Radicals. [PDF]

J Am Chem Soc
Jayaweera AT, Zhang R, Mi J, Rossini AJ, Winter AH.   +4 more
europepmc   +1 more source