Results 41 to 50 of about 75,903 (380)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Adsorption of Aromatic Hydrocarbons on BTEA–Bentonites

Adsorption Science & Technology, 2004
Organobentonites were synthesized using benzyltrimethyl-ammonium bromide (BTEA) with five different exchange degrees. At low concentrations, the amounts of BTEA exchanged did not reach the value of the cation-exchange capacity (CEC) of the bentonite.
N. Yıldız, M. Erol, Z. Aktas, A. Çalımlı   +3 more
doaj   +1 more source

Risk Assessment of Volatile Organic Compounds (VOCs) and Formaldehyde in Korean Public Facilities: Derivation of Health Protection Criteria Levels

Asian Journal of Atmospheric Environment, 2011
This study suggests criteria to conduct a risk assessment of VOCs and formaldehyde in uncontrolled public facilities. Pollutants and facilities were selected based on two years of monitoring data and exposure scenarios in 573 uncontrolled public ...
Ho-Hyun Kim , Young-Wook Lim, Dong-Chun Shin, Jong Ryeul Sohn, Ji-Yeon Yang   +4 more
doaj   +1 more source

On the mechanism of separation of ethanol/water mixtures by pervaporation II. Experimental concentration profiles [PDF]

, 1984
Ethanol—water concentration profiles in cellulose acetate membranes were measured under steady-state pervaporation conditions. Knowledge of these profiles leads to a better understanding of the diffusion process during pervaporation.
Franken, A.C.M., Mulder, M.H.V., Smolders, C.A.   +2 more
core   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Sub-ppb Level Detection of BTEX Gaseous Mixtures with a Compact Prototype GC Equipped with a Preconcentration Unit

Micromachines, 2019
In this work, a compact gas chromatograph prototype for near real-time benzene, toluene, ethylbenzene and xylenes (BTEX) detection at sub-ppb levels has been developed. The system is composed of an aluminium preconcentrator (PC) filled with Basolite C300,
Irene Lara-lbeas, Alberto Rodríguez-Cuevas, Christina Andrikopoulou, Vincent Person, Lucien Baldas, Stéphane Colin, Stéphane Le Calvé   +6 more
doaj   +1 more source

Detection and Quantification of Multi-Analyte Mixtures Using a Single Sensor and Multi-Stage Data-Weighted RLSE [PDF]

, 2018
This work reports the development and experimental verification of a sensor signal processing technique for online identification and quantification of aqueous mixtures of benzene, toluene, ethylbenzene, xylenes (BTEX) and 1, 2, 4-trimethylbenzene (TMB ...
Bender, Florian, Josse, Fabien, PhD, Ricco, Antonio J., Sothivelr, Karthick, Yaz, Edwin E.   +4 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Identification of Volatile Organic Compounds in Several Indoor Public Places in Korea

Asian Journal of Atmospheric Environment, 2014
A comprehensive profile of volatile organic compounds (VOCs) in public spaces is needed for interpreting indoor air measurements. Seasonal differences in profiles are critical for epidemiological study and risk assessment. The purposes of this study were
Sooyun Seo, Soogil Lim, Kiyoung Lee, Young-Kyo Seo, Sung-Ok Baek   +4 more
doaj   +1 more source