Results 51 to 60 of about 22,741,673 (262)

PICH deficiency limits the progression of MYC-induced B-cell lymphoma

Blood Cancer Journal
Plk1-interacting checkpoint helicase (PICH) is a DNA translocase involved in resolving ultrafine anaphase DNA bridges and, therefore, is important to safeguard chromosome segregation and stability.
María Castejón-Griñán, Eliene Albers, Lucía Simón-Carrasco, Paula Aguilera, Mauro Sbroggio, David Pladevall-Morera, Andreas Ingham, Ernest Lim, Alba Guillen-Benitez, Elena Pietrini, Michael Lisby, Ian D. Hickson, Andres J. Lopez-Contreras   +12 more
doaj   +1 more source

Detecting Sex-Biased Gene Flow in African-americans Through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites

Balkan Journal of Medical Genetics, 2012
This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA.
Battaggia C., Anagnostou P., Bosch I., Brisighelli F., Destro-Bisol G., Capocasa M.   +5 more
doaj   +1 more source

X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells

Biology of Sex Differences, 2018
Background Sexual dimorphism in DNA methylation levels is a recurrent epigenetic feature in different human cell types and has been implicated in predisposition to disease, such as psychiatric and autoimmune disorders. To elucidate the genetic origins of
Bianca Ho, Keelin Greenlaw, Abeer Al Tuwaijri, Sanny Moussette, Francisco Martínez, Elisa Giorgio, Alfredo Brusco, Giovanni Battista Ferrero, Natália D. Linhares, Eugênia R. Valadares, Marta Svartman, Vera M. Kalscheuer, Germán Rodríguez Criado, Catherine Laprise, Celia M. T. Greenwood, Anna K. Naumova   +15 more
doaj   +1 more source

Analysis of the Mouse Y Chromosome by Single-Molecule Sequencing With Y Chromosome Enrichment

Frontiers in Genetics, 2020
Since human and mouse Y chromosomes contain repeated sequences, it is difficult to determine the precise sequences and analyze the function of individual Y chromosome genes. Therefore, the causes of many diseases and abnormalities related to Y chromosome
Yuki Yano, Tomoki Chiba, Hiroshi Asahara, Hiroshi Asahara   +3 more
doaj   +1 more source

An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera. [PDF]

PLoS Genetics, 2018
Y chromosomes are widely believed to evolve from a normal autosome through a process of massive gene loss (with preservation of some male genes), shaped by sex-antagonistic selection and complemented by occasional gains of male-related genes.
Eduardo G Dupim, Gabriel Goldstein, Thyago Vanderlinde, Suzana C Vaz, Flávia Krsticevic, Aline Bastos, Thadeo Pinhão, Marcos Torres, Jean R David, Carlos R Vilela, Antonio Bernardo Carvalho   +10 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Chromosome Evolution in New World Monkeys (Platyrrhini) [PDF]

, 2012
During the last decades, New World monkey (NWM, Platyrrhini, Anthropoideae) comparative cytogenetics has shed light on many fundamental aspects of genome organisation and evolution in this fascinating, but also highly endangered group of neotropical ...
Müller, Stefan, Neusser, Michaela, de Oliveira, E. H. C.   +2 more
core   +1 more source

Y-Chromosome Diversity within Siberian Tatars from the Late Medieval Burial Ground Abramovo-10 (Baraba Forest-Steppe)

Вестник Новосибирского государственного университета. Серия: история, филология
Purpose. The paper continues a series of articles devoted to the paleogenetic study of the Late Medieval population from the West Siberian forest-steppe zone.
R. O. Trapezov, I. V. Pilipenko, E. I. Fedoseeva, S. V. Cherdantsev, A. A. Zhuravlev, D. V. Pozdnyakov, M. A. Tomilin, M. P. Rykun, M. S. Nesterova, V. I. Molodin, A. S. Pilipenko   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Tell me y: anticipation of sex discrepancies in cell-free DNA testing due to maternal genetic abnormalities: a case report

Frontiers in Genetics
Sex discordance between cell-free DNA (cfDNA) testing and ultrasound examination is rare but can cause significant patient discomfort and uncertainty.
Nuria Balaguer, Emilia Mateu-Brull, Jose Antonio Martínez-Conejero, Ana Cervero, Roser Navarro, Jorge Jiménez-Almazán, Miguel Milán   +6 more
doaj   +1 more source