Results 91 to 100 of about 10,446,015 (290)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Autosomal suppression of sex-ratio meiotic drive influences the dynamics of X and Y chromosome coevolution [PDF]

, 2023
Anjali Gupta, Robert L. Unckless
openalex   +1 more source

Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. [PDF]

, 2017
Sex chromosomes evolve once recombination is halted between a homologous pair of chromosomes. The dominant model of sex chromosome evolution posits that recombination is suppressed between emerging X and Y chromosomes in order to resolve sexual conflict.
A Kortrschal, A Lindholm, A Loytynoja, A McKenna, A Rimmer, AE Houde, AE Houde, AE Wright, AE Wright, AE Wright, AE Wright, AP Lisachov, AR Quinlan, B Charlesworth, B Langmead, B Sandkam, B Vicoso, B Vicoso, B Vicoso, B Vicoso, BA Fraser, BJA Pollux, C Dufresnes, D Bachtrog, D Bachtrog, D Bachtrog, D Kim, DJ Kemp, DR Kelley, E Axelsson, E Eden, E Eden, E Paradis, G Lunter, H Li, H Li, H Skaletsky, H Skaletsky, I Nanda, J Haldane, J Hough, J Kitano, JA Endler, JA Endler, JA Endler, JA Endler, JE Mank, JE Mank, JE Mank, JE Mank, JE Mank, JP Masly, JRW Russell, K Reichwald, KP Arunkumar, M Lohse, M Pertea, M Stock, M White, M Winge, MD Robinson, MD Robinson, N Tripathi, P Flicek, PW Harrison, Q Zhou, R Bergero, R Chikhi, RA Fisher, RB Luo, RH Devlin, RP Meisel, RP Meisel, RW Meredith, S Anders, SF Altschul, SP Gordon, SP Gordon, T Jombart, T Kamiya, T Lenormand, W Traut, WR Rice, ZH Yang, ZY Liu   +84 more
core   +4 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Repetitive DNA Sequences in the Human Y Chromosome and Male Infertility

Frontiers in Cell and Developmental Biology, 2022
The male-specific Y chromosome, which is well known for its diverse and complex repetitive sequences, has different sizes, genome structures, contents and evolutionary trajectories from other chromosomes and is of great significance for testis ...
Yong Xu, Qianqian Pang
doaj   +1 more source

Y Chromosome Mediates Ribosomal DNA Silencing and Modulates the Chromatin State in Drosophila [PDF]

, 2014
Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked genes. Here we use 15 Y chromosomes
Eickbush, Thomas H., Hartl, Daniel L., Martinsen, Lene, Sackton, Timothy, Silva, Bernardo Lemos, Zhou, Jun   +5 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

Genome Research, 2015
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya).
Monika Karmin, Lauri Saag, M. Vicente, Melissa A. Wilson Sayres, M. Järve, Ulvi Gerst Talas, S. Rootsi, Anne-Mai Ilumäe, R. Mägi, M. Mitt, Luca Pagani, T. Puurand, Zuzana Faltyskova, F. Clemente, A. Cardona, E. Metspalu, Hovhannes Sahakyan, B. Yunusbayev, Georgi Hudjashov, Michael Degiorgio, Eva-Liis Loogväli, Christina A. Eichstaedt, M. Eelmets, G. Chaubey, K. Tambets, S. Litvinov, Maru Mormina, Yali Xue, Q. Ayub, G. Zoraqi, T. Korneliussen, F. Akhatova, J. Lachance, S. Tishkoff, K. Momynaliev, F. Ricaut, Pradiptajati Kusuma, Harilanto Razafindrazaka, Denis Pierron, M. Cox, G. Sultana, R. Willerslev, Craig Muller, Michael C. Westaway, David M. Lambert, V. Škaro, Lejla Kovačević, S. Turdikulova, Dilbar Dalimova, R. Khusainova, Natalya Trofimova, V. Akhmetova, I. Khidiyatova, D. Lichman, J. Isakova, E. Pocheshkhova, Zhaxylyk M. Sabitov, N. Barashkov, P. Nymadawa, E. Mihailov, Joseph Wee Tien Seng, I. Evseeva, A. Migliano, Syafiq Abdullah, George Andriadze, D. Primorac, L. Atramentova, O. Utevska, L. Yepiskoposyan, D. Marjanović, A. Kushniarevich, D. Behar, C. Gilissen, L. Vissers, J. Veltman, E. Balanovska, M. Derenko, B. Malyarchuk, A. Metspalu, S. Fedorova, A. Eriksson, A. Manica, F. Mendez, T. Karafet, K. Veeramah, N. Bradman, M. Hammer, L. Osipova, O. Balanovsky, E. Khusnutdinova, K. Johnsen, M. Remm, Mark George Thomas, C. Tyler-Smith, P. Underhill, E. Willerslev, R. Nielsen, M. Metspalu, R. Villems, T. Kivisild   +99 more
semanticscholar   +1 more source

Patterns of Inter-Chromosomal Gene Conversion on the Male-Specific Region of the Human Y Chromosome [PDF]

, 2017
The male-specific region of the human Y chromosome (MSY) is characterized by the lack of meiotic recombination and it has long been considered an evolutionary independent region of the human genome.
Cruciani, Fulvio, D'Atanasio, Eugenia, Trombetta, Beniamino   +2 more
core   +1 more source