Results 101 to 110 of about 10,690,340 (404)

Precise sequence complementarity between yeast chromosome ends and two classes of just-subtelomeric sequences [PDF]

, 1998
The terminal regions (last 20 kb) of Saccharomyces cerevisiae chromosomes universally contain blocks of precise sequence similarity to other chromosome terminal regions.
Britten, Roy J.
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development.

Cerebral Cortex, 2016
Owing to their unique evolutionary history, modern mammalian X- and Y-chromosomes have highly divergent gene contents counterbalanced by regulatory features, which preferentially restrict expression of X- and Y-specific genes.
A. Raznahan, N. Lee, D. Greenstein, G. Wallace, J. Blumenthal, L. Clasen, J. Giedd   +6 more
semanticscholar   +1 more source

Genetic variants of Y chromosome are associated with a protective lipid profile in black men [PDF]

, 2008
Objective— Gender and ethnicity modulate the phenotypic expression of cardiovascular risk factors. In particular, men are at higher risk of developing cardiovascular diseases compared to women, whereas black populations of African origin display reduced ...
Alfonso Siani, Alfonso Siani, Fabio Lauria, Fabio Lauria, Gianvincenzo Barba, Gianvincenzo Barba, Michelle A. Miller, Michelle A. Miller, O Gianfrancesco, O Gianfrancesco, Paola Russo, Paola Russo, Pasquale Strazzullo, Pasquale Strazzullo, Sharada Karanam, Sharada Karanam, Teresa Esposito, Teresa Esposito   +17 more
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

A new robust diagnostic polymerase chain reaction for determining the mating status of female Anopheles gambiae mosquitoes. [PDF]

, 2007
The principal malaria vector in Africa, Anopheles gambiae, contains two pairs of autosomes and one pair of sex chromosomes. The Y chromosome is only associated with males and other Y chromosome-specific DNA sequences, which are transferred to women ...
Horton, Ashley, Knols, Bart G J, Lanzaro, Gregory C, Ng'habi, Kija R   +3 more
core   +1 more source

Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes [PDF]

, 2016
The X and Y sex chromosomes of placental mammals show hallmarks of a tumultuous evolutionary past. The X Chromosome has a rich and conserved gene content, while the Y Chromosome has lost most of its genes.
Baarends, W.M. (Willy), Gribnau, J.H. (Joost), Grootegoed, J.A. (Anton), Heard, E. (Edith), IJcken, W.F.J. (Wilfred) van, Just, W. (Walter), Mulugeta, E. (Eskeatnaf), Sleddens-Linkels, E. (Esther), Wassenaar, E. (Evelyne)   +8 more
core   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera. [PDF]

PLoS Genetics, 2018
Y chromosomes are widely believed to evolve from a normal autosome through a process of massive gene loss (with preservation of some male genes), shaped by sex-antagonistic selection and complemented by occasional gains of male-related genes.
Eduardo G Dupim, Gabriel Goldstein, Thyago Vanderlinde, Suzana C Vaz, Flávia Krsticevic, Aline Bastos, Thadeo Pinhão, Marcos Torres, Jean R David, Carlos R Vilela, Antonio Bernardo Carvalho   +10 more
doaj   +1 more source

Discovery of Phylogenetic Relevant Y-chromosome Variants in 1000 Genomes Project Data [PDF]

arXiv, 2013
Current Y chromosome research is limited in the poor resolution of Y chromosome phylogenetic tree. Entirely sequenced Y chromosomes in numerous human individuals have only recently become available by the advent of next-generation sequencing technology. The 1000 Genomes Project has sequenced Y chromosomes from more than 1000 males.
arxiv