Results 111 to 120 of about 102,889 (306)

Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives

, 2021
Jiaxin Yong, Yuan Li, Sihan Lin, Zhenning Wang, Yan Xu Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China ...
Li Y, Lin S, Yong J, Wang Z, Xu Y
core  

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Expanding the Hippo pathway : hMOB3 modulates apoptotic MST1 signaling and supports tumor growth in glioblastoma [PDF]

, 2014
Protein kinases are critical players of signal transduction pathways involved in development, physiological and pathological processes. Deregulation of protein kinase signaling is found to be causal or related to varieties of human diseases, such as ...
Tang, Fengyuan
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

YAP LM2, low total YAP:TAZ.bmp

, 2017
YAP siRNA LM2, low total YAP/TAZ.
Chris Bakal (192137), Patricia Pascual Vargas (2925483), Julia Sero (2925480), Vicky Bousgouni (595380), Sam Cooper (2925486), Mar Arias-Garcia (2925477), Springer Nature Admin (428815)   +6 more
core   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Yap Main Island and Yap State, Federated States of Micronesia.

, 2017
Yap Main Island and Yap State, Federated States of Micronesia.
J. Erin Staples (212404), W. Thane Hancock (641873), Marc Fischer (1778896), Martin Bel (641871), Holly Biggs (3804442), Maria Marfel (641869), Tai-Ho Chen (636887), Robert Lanciotti (3804433), Susan L. Hills (3804436), Janeen Laven (463212), Daniel M. Pastula (3804439)   +10 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Emerging role of Hpo signaling and YAP in hepatocellular carcinoma

, 2015
Vicente Valero III,1 Timothy M Pawlik,1 Robert A Anders21Department of Surgery, Division of Surgical Oncology, 2Department of Pathology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Hepatocellular ...
Valero V III, Anders RA, Pawlik TM
core  

Willin as a novel 4.1 ezrin radixin moesin (FERM) domain protein in the mammalian hippo signalling pathway

, 2010
Electronic version excludes material for which permission has not been granted by the rights holderThe Salvador/Warts/Hippo (Hippo) pathway defines a novel signalling cascade regulating cell contact inhibition, organ size control, cell growth ...
Maria Leilani Torres-Mapa, Angus, Liselotte, Liselotte Angus, Frank J. Gunn-Moore, Torres-Mapa, Maria Leilani, Ploschner, Martin, Gunn-Moore, Frank J., Dholakia, Kishan, Martin Ploschner, Kishan Dholakia   +9 more
core   +1 more source