Results 91 to 100 of about 283,339 (312)

Kendin yap

, 2021
İnsanın temel değerleri değişmese de davranışları ya da satın almaya yönelik eylemleri ve tercihleri farklılaşabiliyor. Ama dikkati çeken bir durum var ki eğer bir şeyin üzerinde çok emek sarf edersen ona daha büyük kıymet veriyorsun. Akla o anda Ferhat ile Şirin Efsanesi geliyor.
openaire   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

İşçilerle İlgili Sosyal Sigorta Mevzuatının Gelişimi: “Yap-Boz-Yap” Döngüsünden Çıkılabilir mi?

Sosyal Siyaset Konferansları Dergisi / Journal of Social Policy Conferences, 2022
Türk sosyal sigorta sistemi, sık yapılan müdahalelerle sosyal sigorta haklarını ve yükümlülüklerini düzenleyen mevzuat bakımından adeta “yap-boz-yap” döngüsüne girmiştir. Geçmişte 506 sayılı Sosyal Sigortalar Kanunu ve 5434 Sayılı T.C. Emekli Sandığı Kanunu dağınık sosyal sigorta mevzuatını toplamayı amaçlayan “tek çatı” kanunları olarak yürürlüğe ...
openaire   +3 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

HE AMOT FAMILY OF PROTEINS BINDS AND ACTIVATES NEDD4 FAMILY LIGASES TO PROMOTE THE UBIQUITINATION OF LATS AND YAP [PDF]

, 2012
poster abstractAmot adaptor proteins bind and integrate signaling that controls cell po-larity and growth. All three Amot family members (Amot, AmotL1 and AmotL2) directly bind YAP; a transcriptional co-activator that controls the expression of genes ...
Adler, Jacob J., Heller, Brigitte L., Ingham, Robert J., Tuchek, Chad A., Wells, Clark D.   +4 more
core  

Mechanical and Systems Biology of Cancer [PDF]

, 2018
Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival.
Bakal, Chris, Mak, Michael, Spill, Fabian   +2 more
core   +3 more sources

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, EarlyView.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]

, 2016
Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A., Berasain, Carmen, Brozzetti, Stefania, Calvisi, Diego F., Daino, Lucia, Demartis, Maria I., Feo, Claudio F., Feo, Francesco, Latte, Gavinella, Pascale, Rosa M., Porcu, Alberto, Seddaiu, Maria A., Simile, Maria M., Tomasi, Maria L.   +13 more
core   +2 more sources

A Scalable Perovskite Platform With Multi‐State Photoresponsivity for In‐Sensor Saliency Detection

Advanced Materials, EarlyView.
A scalable in‐sensor computing platform (32 × 32 array) with ultra‐low variability is developed by incorporating ferroelectric copolymers into halide perovskite thin films. These devices achieve 1000 programmable photoresponsivity states and high thermal reliability.
Xuechao Xing, Anubhab Tripathi, Si En Ng, Natalia Yantara, Yue Gong, Qinjie Wu, Yeow Boon Tay, Wen Siang Lew, Yang Chai, Arindam Basu, Nripan Mathews   +10 more
wiley   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source