Results 91 to 100 of about 102,889 (306)
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
, 2022 PURPOSE: The YAP signaling pathway is altered and implicated as oncogenic in human mammary cancers. However, roles of YAP signaling that regulate the breast tumor angiogenesis have remained elusive.
Liang Zhao +9 more
core +1 more source
Damla Sulamada Lateral ve Manifold Boru Çaplarmın Belirlenmesinde Grafiksel Yöntem
Journal of Agricultural Sciences, 1999 Bu çalışmada, damla sulama sistemlerinde, kabul edilebilir düzeyde e ş su dağı l ı m ı sağ lamak amacı yla, lateral ve manifold boru çaplar ı n ı n belirlenmesine yönelik grafiksel çözümler haz ı rlanmışt ı r. Christiansen eş dağı l ı m katsay ı s ı n ı
Osman Yıldırım, Halit Apaydın
doaj
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Paranisitra leytensis Robillard & Yap 2015
, 2019 Paranisitra leytensis Robillard, 2015 (Fig. 1) Paranisitra leytensis Robillard & Yap, 2015: 85; Baroga et al. 2016: 94 (taxonomic key). Type material. Holotype male. Philippines.
Yap, Sheryl A. +3 more
core +1 more source
Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
<p>First release of code for YAP manuscript, relating to figure 6-7, supplemental figure 5, 11, 10</p ...
BivonaLab@UCSF, Lauren Cech
core +1 more source
Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source
Advanced Science, EarlyView.Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu +14 more
wiley +1 more source