Results 71 to 80 of about 283,339 (312)
Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability
Molecular & Cellular Oncology, 2021 Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the production of
Sunghoon Kim, Andrew Wolfe, Sung Eun Kim
doaj +1 more source
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. [PDF]
, 2015 YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size.
Guan, Kun-Liang +7 more
core
Effect of inlet valve timing and water blending on bioethanol HCCI combustion using forced induction and residual gas trapping [PDF]
, 2008 This is the post-print version of the final paper published in Fuel. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other ...
A. Megaritis +5 more
core +1 more source
YAP-Mediated Mechanotransduction in Skeletal Muscle [PDF]
Frontiers in Physiology, 2016 Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and functionality is determined by its mechanical and physical environment. Processing intra- and extracellular mechanical signaling cues contributes to the regulation of cell growth, survival, migration ...
Martina eFischer +4 more
openaire +5 more sources
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Horticulturae, 2019 Cycas micronesica K.D. Hill trees on the island of Yap were used to determine the influence of position along the leaf rachis on macro- and micro-nutrient concentrations and how leaf age affected the results.
Thomas E. Marler +1 more
doaj +1 more source
Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
Molecular & Cellular Oncology, 2021 The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options.
Joel D. Pearson, Rod Bremner
doaj +1 more source
Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. [PDF]
, 2019 Human non‑small cell lung cancer (NSCLC) is associated with an extremely poor prognosis especially for the 40% of patients who develop brain metastasis, and few treatment strategies exist.
Hsu, Ping-Chih +9 more
core
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core +1 more source
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source