Results 1 to 10 of about 30,426 (149)

Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart [PDF]

Nature Communications, 2020
AbstractIntercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. Mutations in genes encoding ICD components are linked to cardiovascular diseases.
Haipeng Guo, Yao Wei Lu, Zhiqiang Lin, Zhan-Peng Huang, Jianming Liu, Yi Wang, Hee Young Seok, Xiaoyun Hu, Qing Ma, Kathryn Li, Jan Kyselovic, Qingchuan Wang, Jenny L.-C. Lin, Jim J.-C. Lin, Douglas B. Cowan, Francisco Naya, Yuguo Chen, William T. Pu, Da-Zhi Wang   +18 more
openaire   +4 more sources

C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes [PDF]

BMB Reports, 2023
C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein ...
Suyeon Jin, Chan Joo Lee, Gibbeum Lim, Sungha Park, Sang-Hak Lee, Ji Hyung Chung, Jaewon Oh, Seok-Min Kang   +7 more
openaire   +2 more sources

Correction to: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling [PDF]

Molecular Cancer, 2021
An amendment to this paper has been published and can be accessed via the original article.
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang   +10 more
openaire   +3 more sources

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein [PDF]

Cell Reports, 2014
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation.
Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh, Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, Xu Wu   +12 more
openaire   +4 more sources

Angelica gigas NAKAI and Its Active Compound, Decursin, Inhibit Cellular Injury as an Antioxidant by the Regulation of AMP-Activated Protein Kinase and YAP Signaling [PDF]

Molecules, 2022
Natural products and medicinal herbs have been used to treat various human diseases by regulating cellular functions and metabolic pathways. Angelica gigas NAKAI (AG) helps regulate pathological processes in some medical fields, including gastroenterology, gynecology, and neuropsychiatry.
Yu-Rim Song, Boyun Jang, Sung-Min Lee, Su-Jin Bae, Seon-Been Bak, Young-Woo Kim   +5 more
openaire   +4 more sources

The LINC01315-encoded small protein YAPer-ORF competes with PRP4k to hijack YAP signaling to aberrantly promote cell growth [PDF]

Cell Death & Differentiation
Abstract The dysregulation of YAP activity is implicated in abnormal organ size and the pathogenesis of diverse diseases, including cancer. However, the functional regulation of YAP activity by lncRNA-encoded peptides remains elusive. In this study, we report the identification of a small protein (93 aa) encoded by the lncRNA LINC01315.
Zhu Xie, Chao Li, Rui Huang, Bo Wu, Qian Huang, Zhe Zhang, Tongjin Zhao, Lingqian Wu, Chengtao Li, Jianfeng Shen, Hongyan Wang   +10 more
openaire   +4 more sources

Understanding the Role of Yes-Associated Protein (YAP) Signaling in the Transformation of Lens Epithelial Cells (EMT) and Fibrosis [PDF]

Biomolecules, 2023
Fibrotic cataracts, posterior capsular opacification (PCO), and anterior subcapsular cataracts (ASC) are mainly attributed to the transforming growth factor-β (TGFβ)-induced epithelial-to-mesenchymal transition (EMT) of lens epithelial cells (LECs). Previous investigations from our laboratory have shown the novel role of non-canonical TGFβ signaling in
Aftab Taiyab, Yasmine Belahlou, Vanessa Wong, Saranya Pandi, Madhu Shekhar, Gowri Priya Chidambaranathan, Judith West-Mays   +6 more
openaire   +4 more sources

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling [PDF]

Molecular Cancer, 2019
Abstract Background It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression through miRNA sponges, they may encode small peptides in tumor pathogenesis.
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang   +10 more
openaire   +4 more sources

P-657 Inhibition of insulin-like growth factor binding protein 4 in granulosa cells extends female fertility age via activation of YAP signaling [PDF]

Human Reproduction
Abstract Study question What role does IGFBP4 play in granulosa cells (GCs) function and ovarian aging, and can targeting IGFBP4 enhance female fertility? Summary answer IGFBP4 inhibits GCs proliferation via YAP signaling.
W Li, Q Hu, F Guo, A Geng, Y A Zeng
openaire   +2 more sources

ECM proteins regulate microRNA-mediated direct reprogramming of fibroblasts into cardiomyocytes via YAP signaling. [PDF]

Front Bioeng Biotechnol
Ruocco G, Nicoletti L, Coletto M, Toccaceli A, Chiono V, Paoletti C.   +5 more
europepmc   +5 more sources