Results 1 to 10 of about 31,444 (137)

Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways

Frontiers in Cell and Developmental Biology, 2020
The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological processes, ranging from cell proliferation, tumorigenesis, mechanosensing and cell lineage ...
Boon C. Heng, Boon C. Heng, Xuehui Zhang, Xuehui Zhang, Dominique Aubel, Yunyang Bai, Xiaochan Li, Yan Wei, Martin Fussenegger, Xuliang Deng, Xuliang Deng   +10 more
doaj   +3 more sources

ECM proteins regulate microRNA-mediated direct reprogramming of fibroblasts into cardiomyocytes via YAP signaling. [PDF]

Front Bioeng Biotechnol
Introduction Direct cardiac reprogramming represents a promising strategy to regenerate damaged myocardium by converting cardiac fibroblasts into induced cardiomyocytes (iCMs). Transient delivery of a four-microRNA cocktail (miRcombo: miR-1, miR-133, miR-208, and miR-499) has been shown to
Ruocco G, Nicoletti L, Coletto M, Toccaceli A, Chiono V, Paoletti C.   +5 more
europepmc   +4 more sources

YAP/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis

Mechanobiology in Medicine
Cardiovascular diseases (CVDs) persistently rank as a leading cause of premature death and illness worldwide. The Hippo signaling pathway, known for its highly conserved nature and integral role in regulating organ size, tissue homeostasis, and stem cell
Rakibul Islam, Zhongkui Hong
doaj   +3 more sources

Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart [PDF]

Nature Communications, 2020
AbstractIntercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. Mutations in genes encoding ICD components are linked to cardiovascular diseases.
Haipeng Guo, Yao Wei Lu, Zhiqiang Lin, Zhan-Peng Huang, Jianming Liu, Yi Wang, Hee Young Seok, Xiaoyun Hu, Qing Ma, Kathryn Li, Jan Kyselovic, Qingchuan Wang, Jenny L.-C. Lin, Jim J.-C. Lin, Douglas B. Cowan, Francisco Naya, Yuguo Chen, William T. Pu, Da-Zhi Wang   +18 more
openaire   +3 more sources

Understanding the Role of Yes-Associated Protein (YAP) Signaling in the Transformation of Lens Epithelial Cells (EMT) and Fibrosis

Biomolecules, 2023
Fibrotic cataracts, posterior capsular opacification (PCO), and anterior subcapsular cataracts (ASC) are mainly attributed to the transforming growth factor-β (TGFβ)-induced epithelial-to-mesenchymal transition (EMT) of lens epithelial cells (LECs). Previous investigations from our laboratory have shown the novel role of non-canonical TGFβ signaling in
Aftab Taiyab, Yasmine Belahlou, Vanessa Wong, Saranya Pandi, Madhu Shekhar, Gowri Priya Chidambaranathan, Judith West-Mays   +6 more
openaire   +3 more sources

Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis

Cell Reports, 2021
Summary: Germline alterations of the NF2 gene cause neurofibromatosis type 2, a syndrome manifested with benign tumors, and Nf2 deletion in mice also results in slow tumorigenesis.
Yu Wang, Yuwen Zhu, Yuan Gu, Mingyue Ma, Yebin Wang, Sixian Qi, Yan Zeng, Rui Zhu, Xueying Wang, Pengcheng Yu, Jianhui Xu, Yilai Shu, Fa-Xing Yu   +12 more
doaj   +1 more source

Correction to: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling [PDF]

Molecular Cancer, 2021
An amendment to this paper has been published and can be accessed via the original article.
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang   +10 more
openaire   +2 more sources

YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells

Analytical Cellular Pathology, 2022
Purpose. The YAP signaling pathway is altered and implicated as oncogenic in human mammary cancers. However, roles of YAP signaling that regulate the breast tumor angiogenesis have remained elusive.
Yu Yan, Qiang Song, Li Yao, Liang Zhao, Hui Cai   +4 more
doaj   +1 more source

Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells. [PDF]

PLoS ONE, 2014
The extracellular environment possesses a rich milieu of biophysical and biochemical signaling cues that are simultaneously integrated by cells and influence cellular phenotype.
Vijay Krishna Raghunathan, Britta Dreier, Joshua T Morgan, Binh C Tuyen, Brad W Rose, Christopher M Reilly, Paul Russell, Christopher J Murphy   +7 more
doaj   +1 more source

YAP/TAZ: Molecular pathway and disease therapy

MedComm, 2023
The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism ...
Yuzi Wei, Victoria Lee Zhi Hui, Yilin Chen, Ruiying Han, Xianglong Han, Yongwen Guo   +5 more
doaj   +1 more source