Results 11 to 20 of about 31,610 (235)

YAP/TAZ: Molecular pathway and disease therapy

MedComm, 2023
The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism ...
Yuzi Wei, Victoria Lee Zhi Hui, Yilin Chen, Ruiying Han, Xianglong Han, Yongwen Guo   +5 more
doaj   +1 more source

C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes

BMB Reports, 2023
C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein ...
Suyeon Jin, Chan Joo Lee, Gibbeum Lim, Sungha Park, Sang-Hak Lee, Ji Hyung Chung, Jaewon Oh, Seok-Min Kang   +7 more
openaire   +1 more source

Yes-associated protein (YAP) signaling regulates lipopolysaccharide-induced tissue factor expression in human endothelial cells [PDF]

Surgery, 2016
Sepsis-induced acute lung injury (ALI) is characterized by fibrin deposition, which indicates the local activation of coagulation. Tissue factor (TF), expressed in the pulmonary microvasculature, acts as a critical initiator of blood coagulation and ALI in sepsis.
Lei, Yi, Xiaoqin, Huang, Feng, Guo, Zengding, Zhou, Yi, Dou, Jingning, Huan   +5 more
openaire   +2 more sources

YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas

Cancer Cell International, 2021
Background Autophagy is a double-edged sword during the initiation and progression of multiple tumors. The Hippo pathway effector YAP has been proved to be involved in autophagy processes.
Wei Xu, Mingjiong Zhang, Yue Li, Yu Wang, Kai Wang, Qiaoyu Chen, Runjie Zhang, Weiwei Song, Qiqing Huang, Weihong Zhao, Jianqing Wu   +10 more
doaj   +1 more source

Angelica gigas NAKAI and Its Active Compound, Decursin, Inhibit Cellular Injury as an Antioxidant by the Regulation of AMP-Activated Protein Kinase and YAP Signaling

Molecules, 2022
Natural products and medicinal herbs have been used to treat various human diseases by regulating cellular functions and metabolic pathways. Angelica gigas NAKAI (AG) helps regulate pathological processes in some medical fields, including gastroenterology, gynecology, and neuropsychiatry.
Yu-Rim Song, Boyun Jang, Sung-Min Lee, Su-Jin Bae, Seon-Been Bak, Young-Woo Kim   +5 more
openaire   +3 more sources

BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation

Advanced Science, 2022
Rho GTPases and Hippo kinases are key regulators of cardiomyoblast differentiation. However, how these signaling axes are coordinated spatiotemporally remains unclear. Here, the central and multifaceted roles of the BCH domain containing protein, BNIP‐2,
Darren Chen Pei Wong, Jingwei Xiao, Ti Weng Chew, Meng Pan, Chang Jie Mick Lee, Jing Wen Ang, Ivan Yow, T. Thivakar, Matthew Ackers‐Johnson, Nicole Jia Wen Lee, Roger Sik‐Yin Foo, Pakorn Kanchanawong, Boon Chuan Low   +12 more
doaj   +1 more source

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling [PDF]

Molecular Cancer, 2019
Abstract Background It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression through miRNA sponges, they may encode small peptides in tumor pathogenesis.
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang   +10 more
openaire   +3 more sources

Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade

Veterinary Quarterly, 2021
The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus.
Shaydee J. Budel, Marloes M. Penning, Louis C. Penning   +2 more
doaj   +1 more source

α-Hederin Inhibits the Proliferation of Hepatocellular Carcinoma Cells via Hippo-Yes-Associated Protein Signaling Pathway

Frontiers in Oncology, 2022
AimsYes-associated protein (YAP), a downstream protein in the Hippo signaling pathway, plays an important role in tumor proliferation, including in hepatocellular carcinoma (HCC).
Tongqing Chen, Dongdong Sun, Qijuan Wang, Tingting Zhou, Jiani Tan, Changliang Xu, Haibo Cheng, Weixing Shen   +7 more
doaj   +1 more source

Role and mechanism of leukemia inhibitory factor receptor in cervical cancer invasion and metastasis

Journal of International Medical Research, 2023
Objective To investigate the relationships of leukemia inhibitory factor receptor (LIFR) with cervical cancer invasion and metastasis. Methods From January 2021 to December 2022, 45 patients treated for cervical cancer and lung metastases were identified.
Hengfen Hu, Qihui Zhao, Yufei Sang, Yanqing Xiao, Na Jiang   +4 more
doaj   +1 more source