Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival [PDF]
Signal Transduction and Targeted Therapy, 2018 Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious treatment modalities. Elucidation of signaling mechanisms that will lead to the identification of novel targets for therapy and chemoprevention is urgently needed ...
Enrique Rozengurt +2 more
exaly +7 more sources
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways
Frontiers in Cell and Developmental Biology, 2020 The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological processes, ranging from cell proliferation, tumorigenesis, mechanosensing and cell lineage ...
Boon C. Heng +10 more
doaj +3 more sources
SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis. [PDF]
PLoS ONEObjectiveTo look into the molecular processes and function of SHP2 in late-onset fetal growth restriction (LO-FGR).MethodsAn elaborate research technique included in vitro experiments and bioinformatics analysis.
Fang Li +8 more
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Novel roles of the junctional protein associated with coronary artery disease in regulating Hippo‐YAP signalling axis to improve liver regenerative potential [PDF]
Clinical and Translational DiscoveryEltyeb Abdelwahid
openaire +3 more sources
Cell Reports, 2021 Summary: Germline alterations of the NF2 gene cause neurofibromatosis type 2, a syndrome manifested with benign tumors, and Nf2 deletion in mice also results in slow tumorigenesis.
Yu Wang +12 more
doaj +1 more source
Analytical Cellular Pathology, 2022 Purpose. The YAP signaling pathway is altered and implicated as oncogenic in human mammary cancers. However, roles of YAP signaling that regulate the breast tumor angiogenesis have remained elusive.
Yu Yan +4 more
doaj +1 more source
Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells. [PDF]
PLoS ONE, 2014 The extracellular environment possesses a rich milieu of biophysical and biochemical signaling cues that are simultaneously integrated by cells and influence cellular phenotype.
Vijay Krishna Raghunathan +7 more
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Yes-associated protein (YAP) signaling regulates lipopolysaccharide-induced tissue factor expression in human endothelial cells [PDF]
Surgery, 2016 Sepsis-induced acute lung injury (ALI) is characterized by fibrin deposition, which indicates the local activation of coagulation. Tissue factor (TF), expressed in the pulmonary microvasculature, acts as a critical initiator of blood coagulation and ALI in sepsis.
Lei, Yi +5 more
openaire +2 more sources
YAP/TAZ: Molecular pathway and disease therapy
MedComm, 2023 The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism ...
Yuzi Wei +5 more
doaj +1 more source
YAP and endothelin-1 signaling: an emerging alliance in cancer
Journal of Experimental & Clinical Cancer Research, 2021 The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies.
Piera Tocci +2 more
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