Results 31 to 40 of about 31,444 (137)

Hippo in smooth muscle - a therapeutic target in vascular diseases driven by aging and hypertension

Frontiers in Physiology
IntroductionThe Hippo signaling pathway is a key regulator of cellular growth and organ size, acting through the transcriptional coactivators YAP and TAZ.
Sebastian Albinsson, Catarina Rippe, Fatima Daoud, Fatima Daoud, Joakim Armstrong Bastrup, Johan Holmberg, Thomas A. Jepps, Karl Swärd   +7 more
doaj   +1 more source

Electroacupuncture alleviates neurological function via activating the Yap-OPA1 axis and mitochondrial fusion in rats with cerebral ischemia-reperfusion injury

针刺研究, 2023
ObjectiveTo investigate the mechanism of electroacupuncture （EA） in alleviating cerebral ische-mia injury by activating the Yap-OPA1 signaling axis.MethodsA total of 48 male SD rats were used in the present study.
LIANG Hui, RUAN Su, WANG Fang, YAN Nian-wen, WANG Yan-xu, CHEN Bin, LUO Jing, LIU Jia-jing, ZHONG Xiao-yong   +8 more
doaj  

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

iScience, 2021
Summary: Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative ...
Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, Kaja Lund, Nina Therese Solberg, Max Lycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Ståle Nygård, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, Jo Waaler   +20 more
doaj   +1 more source

Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.

PLoS Genetics, 2020
The Hippo signalling pathway and its central effector YAP regulate proliferation of cardiomyocytes and growth of the heart. Using genetic models in mice we show that the increased proliferation of embryonal and postnatal cardiomyocytes due to loss of the
Marco Gründl, Susanne Walz, Laura Hauf, Melissa Schwab, Kerstin Marcela Werner, Susanne Spahr, Clemens Schulte, Hans Michael Maric, Carsten P Ade, Stefan Gaubatz   +9 more
doaj   +1 more source

Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion

Frontiers in Cell and Developmental Biology, 2023
Breast cancer is characterized by physical changes that occur in the tumor microenvironment throughout growth and metastasis of tumors. Extracellular matrix stiffness increases as tumors develop and spread, with stiffer environments thought to correlate ...
Irina Jahin, Thomas Phillips, Stefania Marcotti, Mark-Alexander Gorey, Susan Cox, Maddy Parsons   +5 more
doaj   +1 more source

GPCR-Hippo Signaling in Cancer

Cells, 2019
The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies
Jiaqian Luo, Fa-Xing Yu
doaj   +1 more source

The LINC01315-encoded small protein YAPer-ORF competes with PRP4k to hijack YAP signaling to aberrantly promote cell growth

Cell Death & Differentiation
Abstract The dysregulation of YAP activity is implicated in abnormal organ size and the pathogenesis of diverse diseases, including cancer. However, the functional regulation of YAP activity by lncRNA-encoded peptides remains elusive. In this study, we report the identification of a small protein (93 aa) encoded by the lncRNA LINC01315.
Zhu Xie, Chao Li, Rui Huang, Bo Wu, Qian Huang, Zhe Zhang, Tongjin Zhao, Lingqian Wu, Chengtao Li, Jianfeng Shen, Hongyan Wang   +10 more
openaire   +3 more sources

OSBPL3 drives colorectal cancer progression via Hippo-YAP signaling and modulates MEK inhibitor sensitivity

Communications Biology
Colorectal cancer progression involves dysregulated signaling pathways such as Hippo-YAP, but upstream regulators remain poorly defined. Here we demonstrate that oxysterol-binding protein-like 3 (OSBPL3) modulates Hippo-YAP signaling to drive tumor ...
Yuchen Zhong, Chaojing Zheng, Zitong Wang, Weiyuan Zhang, Hongyu Wu, Jun Luo, Hao Zhang, Chunlin Wang, Chenkai Zhang, Hanqing Hu, Ziming Yuan, Meng Wang, Qian Zhang, Guiyu Wang   +13 more
doaj   +1 more source

Angiomotin Regulates YAP Localization during Neural Differentiation of Human Pluripotent Stem Cells

Stem Cell Reports, 2019
Summary: Leveraging the extraordinary potential of human pluripotent stem cells (hPSCs) requires an understanding of the mechanisms underlying cell-fate decisions.
Yefim Zaltsman, Sayaka Masuko, Joshua J. Bensen, Laura L. Kiessling   +3 more
doaj   +1 more source

Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

eLife, 2019
WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-
Zhijie Lin, Zhou Yang, Ruiling Xie, Zeyang Ji, Kunliang Guan, Mingjie Zhang   +5 more
doaj   +1 more source