Results 51 to 60 of about 31,444 (137)

Blockade of Crk eliminates Yki/YAP-activated tumors via JNK-mediated apoptosis in Drosophila

Communications Biology
Selective elimination of cancer cells without causing deleterious effects on normal cells is an ideal anti-cancer strategy. Here, using Drosophila cancer model, we performed an in vivo RNAi screen for anti-cancer targets that selectively eliminate tumors
Bungo Kakemura, Tatsushi Igaki
doaj   +1 more source

CXCR7 promoted proliferation, migration and invasion in HCC Cells by inactivating Hippo-YAP signaling

Discover Oncology
Background CXCR7 (ACKR3) has been well-supported as a promoter of growth and metastasis in hepatocellular carcinoma (HCC). Both CXCR7 and Hippo signaling play roles in organ development.
Genwang Wang, Yu Pang, Nan Li, Yongfeng Hui, Dong Jin   +4 more
doaj   +1 more source

ER stress-induced YAP upregulation leads to chondrocyte phenotype loss in age-related osteoarthritis

Frontiers in Pharmacology
BackgroundOsteoarthritis (OA) is a common degenerative joint disease, leading to pain and restricted mobility. Age-related endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of OA, but the underlying mechanisms remain unclear. This
Yanchun Gao, Haifeng Wei, Xiaoyuan Peng, Chenchen Wang, Hongyi Zhu, Junhui Yin   +5 more
doaj   +1 more source

IQGAP1 participates in endothelial cell apoptosis and regulates atherosclerosis by targeting YAP.

PLoS ONE
Endothelial cell (EC) apoptosis plays a crucial role in the onset and progression of atherosclerosis (AS). IQGAP1 is highly expressed in various tissues and affects cell growth, development and death. However, the complete elucidation of the influence of
Shaojun Huang, Yao Cheng, Chengxin Zhang
doaj   +1 more source

The relationship between sperm secretion and the Hippo signaling pathway in the rat seminiferous tubules

Scientific Reports
The Hippo signaling pathway has been demonstrated to be crucial in many stages such as cell division, death, or proliferation. Studies have also shown that the Hippo pathway is highly influenced by actin proteins and cytoskeletons.
İrem İnanç, Onur Bender, Arzu Atalay, Esra Erdemli   +3 more
doaj   +1 more source

Effects of formaldehyde on YAP and NF-κB signaling pathways in mammalian cells

Results in Chemistry
Formaldehyde is the smallest existing aldehyde, a highly reactive color less gas at room temperature and ubiquitously present in our atmosphere. Because of its reactivity leading to the crosslinking of macromolecules like proteins, it is widely used in ...
Katharina Ostmann, Annette Kraegeloh, Wilfried Weber   +2 more
doaj   +1 more source

The Hippo Signaling Pathway, Reactive Oxygen Species Production, and Oxidative Stress: A Two-Way Traffic Regulation

Cells
The Hippo signaling pathway is recognized for its significant role in cell differentiation, proliferation, survival, and tissue regeneration. Recently, the Hippo signaling pathway was also found to be associated with oxidative stress and reactive oxygen ...
Bella Amanda, Rangga Pragasta, Haris Cakrasana, Arifa Mustika, Zakiyatul Faizah, Delvac Oceandy   +5 more
doaj   +1 more source

YAP activity protects against ventilator-induced lung injury

Frontiers in Physiology
IntroductionMechanical ventilation (MV) activates inflammatory signaling pathways, leading to ventilator-induced lung injury (VILI), the activation of lung repair processes, persistent inflammatory stimulation and incomplete tissue repair leads to ...
Huan Liu, Huan Liu, Xuepeng Yang, Feng Qi, Xuan Li, Xuan Li, Yu Liu, Yu Liu, Ge Liu, Xiaojie Lin   +9 more
doaj   +1 more source

Expression of Core Hippo Pathway Proteins in Cervical Cancer and Their Association with Clinicopathologic Parameters

Medicina
Background: The Hippo signaling pathway, a highly conserved regulatory cascade, regulates tissue homeostasis, organ size, and tumor suppression. Dysregulation of this pathway contributes to oncogenesis in various human malignancies; however, its ...
Min Hye Kim, Juseok Yang, Dae Hyun Song, Cho Hee Kim, Jeong Kyu Shin, Won Jun Choi, Jong Chul Baek   +6 more
doaj   +1 more source

VGLL4-driven TEAD4 multimerization orchestrates DNA binding and YAP recruitment

Nature Communications
The Hippo pathway, a highly conserved kinase signaling cascade, is central to regulating cell growth and proliferation, tissue homeostasis, and organ development.
Zhiyun Ren, Yilin Zhao, Wentao Yu, Xia Zhang, Xiaoxuan Song, Yanling Bao, Meng Hu, Lishuang Chen, Hao Yang, Bingkai Cheng, Cong Liu, Yunyun Jin, Lei Zhang, Bo Sun   +13 more
doaj   +1 more source