Results 41 to 50 of about 60,617 (307)

Crosstalk Among YAP, LncRNA, and Tumor-Associated Macrophages in Tumorigenesis Development

Frontiers in Oncology, 2022
Long non-coding RNAs (ncRNAs), which do not encode proteins, regulate cell proliferation, tumor angiogenesis, and metastasis and are closely associated with the development, progression, and metastasis of many cancers. Tumor-associated macrophages (TAMs)
Jing Xu, Jing Xu, Xin-Yuan Liu, Qi Zhang, Hua Liu, Peng Zhang, Zi-Bin Tian, Cui-Ping Zhang, Xiao-Yu Li   +8 more
doaj   +1 more source

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. [PDF]

, 2015
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ.
Flores, Fabian, Guan, Kun-Liang, Halder, Georg, Hansen, Carsten G, Hong, Audrey W, Lu, Shicong, Lu, Wenqi, Meng, Zhipeng, Mo, Jung-Soon, Moroishi, Toshiro, Mottier-Pavie, Violaine, Park, Hyun Woo, Plouffe, Steven W, Yu, Fa-Xing   +13 more
core   +2 more sources

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells [PDF]

, 2020
The topographic features of an implant, which mechanically regulate cell behaviors and functions, are critical for the clinical success in tissue regeneration.
Camacho, Luis Cuellar, Haag, Rainer, Hou, Yong, Nie, Chuanxiong, Wei, Qiang, Xie, Wenyan, Yu, Leixiao, Zhang, Man   +7 more
core   +1 more source

Mechanical and Systems Biology of Cancer [PDF]

, 2018
Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival.
Bakal, Chris, Mak, Michael, Spill, Fabian   +2 more
core   +3 more sources

Hippo in smooth muscle - a therapeutic target in vascular diseases driven by aging and hypertension

Frontiers in Physiology
IntroductionThe Hippo signaling pathway is a key regulator of cellular growth and organ size, acting through the transcriptional coactivators YAP and TAZ.
Sebastian Albinsson, Catarina Rippe, Fatima Daoud, Fatima Daoud, Joakim Armstrong Bastrup, Johan Holmberg, Thomas A. Jepps, Karl Swärd   +7 more
doaj   +1 more source

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

iScience, 2021
Summary: Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative ...
Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, Kaja Lund, Nina Therese Solberg, Max Lycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Ståle Nygård, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, Jo Waaler   +20 more
doaj   +1 more source

Histone Acetylation-Mediated Regulation of the Hippo Pathway [PDF]

, 2013
The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer treatment.
A Rebbaa, A Salic, Abdelhadi Rebbaa, Ali J. Marian, B Zhao, B Zhao, BL Mirkin, BR Mardin, BS Robinson, C Alarcon, C Zhang, CA Thorne, D Basu, D Lai, Dipanjan Basu, E Miller, E Pazolli, F Chu, F Kanai, F Martin-Belmonte, FA Grusche, FX Yu, G Halder, H Oh, H Oh, HH Cho, HJ Chen, HM Prince, I Lian, J Avruch, J Zhang, JP Lyons, K Harvey, KF Harvey, KF Harvey, L Azzolin, L Zender, L Zhao, LM McCaffrey, M Cordenonsi, M Sudol, MA St John, Miguel Reyes-Múgica, NA Grzeschik, QY Lei, RS Udan, S Wu, SA Mousa, T de Cristofaro, T Xu, W Huang, WM Konsavage Jr, X Varelas, X Varelas, XJ Li, Y Hao, Y Liu, Y Wang, Z Zhou   +58 more
core   +3 more sources

Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.

PLoS Genetics, 2020
The Hippo signalling pathway and its central effector YAP regulate proliferation of cardiomyocytes and growth of the heart. Using genetic models in mice we show that the increased proliferation of embryonal and postnatal cardiomyocytes due to loss of the
Marco Gründl, Susanne Walz, Laura Hauf, Melissa Schwab, Kerstin Marcela Werner, Susanne Spahr, Clemens Schulte, Hans Michael Maric, Carsten P Ade, Stefan Gaubatz   +9 more
doaj   +1 more source

YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation [PDF]

, 2019
Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis.
Amicone, Laura, Battistelli, Cecilia, Cicchini, Carla, Consalvi, Veronica, Cozzolino, Angela Maria, Marchetti, Alessandra, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco   +8 more
core   +1 more source

Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion

Frontiers in Cell and Developmental Biology, 2023
Breast cancer is characterized by physical changes that occur in the tumor microenvironment throughout growth and metastasis of tumors. Extracellular matrix stiffness increases as tumors develop and spread, with stiffer environments thought to correlate ...
Irina Jahin, Thomas Phillips, Stefania Marcotti, Mark-Alexander Gorey, Susan Cox, Maddy Parsons   +5 more
doaj   +1 more source