Results 21 to 30 of about 31,444 (137)

α-Hederin Inhibits the Proliferation of Hepatocellular Carcinoma Cells via Hippo-Yes-Associated Protein Signaling Pathway

Frontiers in Oncology, 2022
AimsYes-associated protein (YAP), a downstream protein in the Hippo signaling pathway, plays an important role in tumor proliferation, including in hepatocellular carcinoma (HCC).
Tongqing Chen, Dongdong Sun, Qijuan Wang, Tingting Zhou, Jiani Tan, Changliang Xu, Haibo Cheng, Weixing Shen   +7 more
doaj   +1 more source

Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling

Molecular Biology of the Cell, 2015
Epithelial cells are major sites of malignant transformation. Atypical protein kinase C (aPKC) isoforms are overexpressed and activated in many cancer types. Using normal, highly polarized epithelial cells (MDCK and NMuMG), we report that aPKC gain of function overcomes contact inhibited growth and is sufficient for a transformed epithelial phenotype.
Archibald, Andrew, Al-Masri, Maia, Liew-Spilger, Alyson, McCaffrey, Luke   +3 more
openaire   +2 more sources

Super-Enhancer-Associated LncRNA UCA1 Interacts Directly with AMOT to Activate YAP Target Genes in Epithelial Ovarian Cancer

iScience, 2019
Summary: Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumorigenesis, and yet their mechanistic roles remain challenging to characterize.
Xianzhi Lin, Tassja J. Spindler, Marcos Abraão de Souza Fonseca, Rosario I. Corona, Ji-Heui Seo, Felipe Segato Dezem, Lewyn Li, Janet M. Lee, Henry W. Long, Thomas A. Sellers, Beth Y. Karlan, Houtan Noushmehr, Matthew L. Freedman, Simon A. Gayther, Kate Lawrenson   +14 more
doaj   +1 more source

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

Cell Reports, 2014
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation.
Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh, Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, Xu Wu   +12 more
openaire   +3 more sources

The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling

Cells, 2019
Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated.
Ryan E. Hillmer, Brian A. Link
doaj   +1 more source

Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells.

PLoS Pathogens, 2021
The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell malignancies, and both the latent and lytic forms of viral infection contribute to the development of EBV-associated tumors.
Nicholas Van Sciver, Makoto Ohashi, Nicholas P Pauly, Jillian A Bristol, Scott E Nelson, Eric C Johannsen, Shannon C Kenney   +6 more
doaj   +1 more source

YAP Promotes Cell Proliferation and Stemness Maintenance of Porcine Muscle Stem Cells under High-Density Condition

Cells, 2021
Muscle stem cells (MuSCs) isolated ex vivo are essential original cells to produce cultured meat. Currently, one of the main obstacles for cultured meat production derives from the limited capacity of large-scale amplification of MuSCs, especially under ...
Zheng Liu, Ling Lin, Haozhe Zhu, Zhongyuan Wu, Xi Ding, Rongrong Hu, Yichen Jiang, Changbo Tang, Shijie Ding, Renpeng Guo   +9 more
doaj   +1 more source

WW Domain-Containing Proteins YAP and TAZ in the Hippo Pathway as Key Regulators in Stemness Maintenance, Tissue Homeostasis, and Tumorigenesis

Frontiers in Oncology, 2019
The Hippo pathway is a conserved signaling pathway originally defined in Drosophila melanogaster two decades ago. Deregulation of the Hippo pathway leads to significant overgrowth in phenotypes and ultimately initiation of tumorigenesis in various ...
Yu-An Chen, Chen-Yu Lu, Tian-You Cheng, Szu-Hua Pan, Hsin-Fu Chen, Hsin-Fu Chen, Nan-Shan Chang, Nan-Shan Chang, Nan-Shan Chang   +8 more
doaj   +1 more source

Crosstalk Among YAP, LncRNA, and Tumor-Associated Macrophages in Tumorigenesis Development

Frontiers in Oncology, 2022
Long non-coding RNAs (ncRNAs), which do not encode proteins, regulate cell proliferation, tumor angiogenesis, and metastasis and are closely associated with the development, progression, and metastasis of many cancers. Tumor-associated macrophages (TAMs)
Jing Xu, Jing Xu, Xin-Yuan Liu, Qi Zhang, Hua Liu, Peng Zhang, Zi-Bin Tian, Cui-Ping Zhang, Xiao-Yu Li   +8 more
doaj   +1 more source

YAP and TAZ Regulate Cc2d1b and Purβ in Schwann Cells

Frontiers in Molecular Neuroscience, 2019
Schwann cells (SCs) are exquisitely sensitive to the elasticity of their environment and their differentiation and capacity to myelinate depend on the transduction of mechanical stimuli by YAP and TAZ. YAP/TAZ, in concert with other transcription factors,
Sophie Belin, Jacob Herron, Jordan J. S. VerPlank, Yungki Park, Laura M. Feltri, Laura M. Feltri, Yannick Poitelon   +6 more
doaj   +1 more source