Results 191 to 200 of about 62,440 (265)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Creatine metabolism regulates trophectoderm formation in early mouse embryos via an energy-cytoskeleton-YAP axis. [PDF]

J Biol Chem
Chen X, Pan B, Qin J, Wei Y, Du K, Ning A, Sun T, Wang C, Zou S, Su X, Wang M, Guo Y, Xiong X, Pei S, Zang S, Zhang C, Ye J, Yu G, Liang Q, Zhou G.   +19 more
europepmc   +1 more source

Transcriptional signatures of cortical morphometric variability in temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Widespread cognitive deficits in temporal lobe epilepsy (TLE) are associated with macroscale brain structural changes. However, the correlation between the changes in the cortical morphological similarity of the TLE and gene expression remains unclear.
Yaping Dong, Shuai Wang, Jingjie Luo, Juan Meng, Yuanmei Liu, Song Zhang   +5 more
wiley   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source

Vitamin D receptor isoform VDRA suppresses hepatocellular tumorigenesis by restricting YAP nuclear localization. [PDF]

Cell Death Dis
Li L, He S, Wang R, Wang J, Zheng Z, Wang Z, Li B, Ye W, Wang P.   +8 more
europepmc   +1 more source

Laser‐assisted in situ fabrication of atomically thin Ga2O3 films for dielectric applications

FlexMat, EarlyView.
A confinement template‐assisted squeeze method, in conjunction with laser‐assisted in situ oxidation, facilitates fabrication of centimeter‐scale and atomically thin gallium oxide films from liquid gallium under room temperature conditions. This low‐damage approach avoids thermal degradation of sensitive materials and supports high‐performance field ...
Erzhuo Zhang, Guangyu Yang, Qiwei Sun, Jing Liu, Han Wang, Junran Zhang, Junlei Zhao, Lin Wang, Mengyuan Hua, Xiaolong Chen   +9 more
wiley   +1 more source

NELFA-mediated pausing restrains YAP transcription and context-dependent outcomes in breast cancer. [PDF]

Front Oncol
Vasave BS, Atreya AA, Kulkarni RD, Nagarkar SS, Salvi KR, Koppiker CB, Shashidhara LS, Kulkarni MD.   +7 more
europepmc   +1 more source

Chiral perovskites for next‐generation chiral optoelectronics and spintronics

FlexMat, EarlyView.
Benefiting from structural inversion symmetry breaking and strong spin‐orbit coupling, chiral perovskites possess intriguing chiral optical and spin properties. We overview their advances and core applications in perovskite solar cells, circularly polarized light detectors and spin circularly polarized‐light‐emitting diodes, offering great potential ...
Mengyao Zhang, Rui Xu, Xueyan Hou, Sihan Du, Mengting Xu, Jia Wu, Zhichao Lin, Pei Liu, Qiang Zhuang, Xiaoming Zhao, Yang Yang, Wenda Shi, Wanlin Guo, Jie Kong   +13 more
wiley   +1 more source

Stress-induced CXCL13 regulates pancreatic exocrine homeostasis, age-related chronic inflammation, and cancer progression. [PDF]

Sci Adv
Yoshida M, Furuyama K, Sumide K, Horiguchi M, Abo-Ahmed AI, Shibata H, Tanaka A, Rashwan AM, Masui T, Alev C, Yamamoto T, Yamada Y, Kaneko S, Narumiya S, Tuveson D, Uemoto S, Hatano E, Kawaguchi Y.   +17 more
europepmc   +1 more source

Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration

Biology Open
Victoria Hyland, M. Kathryn Iovine
doaj   +1 more source