Results 131 to 140 of about 176,467,119 (306)

Decreasing incidence of surgery in the six birth-year cohorts.

open access: yes, 2018
Decreasing incidence of surgery in the six birth-year cohorts.
Likwang Chen (111860)   +3 more
core   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong   +20 more
wiley   +1 more source

From the Cradle to the Labor Market? The Effect of Birth Weight on Adult Outcomes [PDF]

open access: yes
Lower birth weight babies have worse outcomes, both short-run in terms of one year mortality rates and longer run in terms of educational attainment and earnings.However, recent research has called into question whether birth weight itself is important ...
Sandra E. Black   +2 more
core  

Area disadvantage and mental health over the life course: a 69-year prospective birth cohort study. [PDF]

open access: yesSoc Psychiatry Psychiatr Epidemiol, 2023
Bakolis I   +4 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang   +8 more
wiley   +1 more source

The relative age in handball players in Portugal

open access: yesE-balonmano.com: Revista de Ciencias del Deporte, 2020
Relative age effect is a subject that has been studied as a differentiating factor between athletes’ development. This study aimed to determine whether handball players have more possibilities to get to high performance, according to the month and year ...
Paulo Sá   +4 more
doaj  

A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair

open access: yesAdvanced Science, EarlyView.
ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang   +16 more
wiley   +1 more source

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