Results 171 to 180 of about 650,029 (311)

Inclusion of older adults in UK clinical research-the National Institute for Health and Care Research Year of Birth Project. [PDF]

Age Ageing
Patel M, Tiwari D, Anwar S, Evans P, Meersschaert C, Minhas JS, Masoli JAH, Quinn TJ.   +7 more
europepmc   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Breastfeeding at one year after birth: duration and associated factors in primiparous women in Sweden - a longitudinal study. [PDF]

Int Breastfeed J
Johansson C, Hildingsson I, Edqvist M, Bonnevier A, Rubertsson C.   +4 more
europepmc   +1 more source

Exploring the use of health and wellbeing measures during pregnancy and the first year following birth in women living with pre-existing long-term conditions: qualitative interviews with women and healthcare professionals. [PDF]

BMC Health Serv Res, 2021
Kelly L, Kurinczuk JJ, Rivero-Arias O, Fitzpatrick R, Gibbons E, Alderdice F.   +5 more
europepmc   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Diagnostic performance of ultrasound in identifying early knee osteoarthritis features in a 33-year-old birth cohort. [PDF]

Osteoarthr Cartil Open
Pihl O, Halonen K, Saarakkala S, Nevalainen MT, Kemppainen A.   +4 more
europepmc   +1 more source

Adverse Childhood Experiences are associated with choice of partner, both partners' relationship and psychosocial health as reported one year after birth of a common child. A cross-sectional study. [PDF]

PLoS One, 2021
Andersson SO, Annerbäck EM, Söndergaard HP, Hallqvist J, Kristiansson P.   +4 more
europepmc   +1 more source

Birth of JAD: 20 Years Later

Journal of Alzheimer’s Disease, 2018
Perry, George, Avila, Jesus, Tabaton M., Zhu, Xiongwei   +3 more
openaire   +4 more sources

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

Advanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang, Yadong Yang, Yongsheng Wang, Guirui Yu   +3 more
wiley   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source