Results 131 to 140 of about 78,875 (281)

An analysis of the global, regional, and national burden of blindness and vision loss between 1990 and 2021: the findings of the Global Burden of Disease Study 2021

Frontiers in Public Health
ObjectivesTo evaluate the global burden of blindness and vision loss (BVL) from 1990 to 2021 using a retrospective analysis of epidemiological data from Global Burden of Disease (GBD) study 2021 and to project trends over the next 15 years.MethodsThis ...
Lijuan Que, Qin Zhu, Chun Jiang, Qianyi Lu   +3 more
doaj   +1 more source

Register-based metrics of years lived with disability associated with mental and substance use disorders: a register-based cohort study in Denmark [PDF]

, 2021
Nanna Weye, Damian Santomauro, Esben Agerbo, Maria Klitgaard Christensen, Kim Moesgaard Iburg, Natalie C. Momen, Preben Bo Mortensen, Carsten Bøcker Pedersen, Harvey Whiteford, John J. McGrath, Oleguer Plana‐Ripoll   +10 more
openalex   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Burden of Parkinson’s disease in Central Asia from 1990 to 2021: findings from the Global Burden of Disease study

BMC Neurology
Background Central Asia is known to face various ecological challenges that constitutes major risk factors for Parkinson’s disease (PD). This study examines the burden of PD in Central Asia, a region where data on neurological disorders is notably sparse.
Ruslan Akhmedullin, Adil Supiyev, Rauan Kaiyrzhanov, Alpamys Issanov, Abduzhappar Gaipov, Antonio Sarria-Santamera, Raushan Tautanova, Byron Crape   +7 more
doaj   +1 more source

BeBOD estimates of mortality, years of life lost, prevalence, years lived with disability, and disability-adjusted life years for 38 causes, 2013-2020

, 2023
Robby De Pauw, Vanessa Gorasso, Aline Scohy, Laura Van den Borre, Brecht Devleesschauwer   +4 more
openalex   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

The impact of COVID-19: consequences of a 3-Year struggle in Iran

BMC Infectious Diseases
Background The disability-adjusted life year (DALY) approach gives policymakers a clear understanding of the scale of the health issue. This study aimed to estimate DALYs attributed to coronavirus disease 2019 (COVID-19) for the population of Bushehr ...
Habib Omranikhoo, Hedayat Salari, Khosro Keshavarz, Marziyeh Rajabi, Mehdi Rezaee   +4 more
doaj   +1 more source

Incidence, Morbidity and years Lived With Disability due to Type 2 Diabetes Mellitus in 204 Countries and Territories: Trends From 1990 to 2019. [PDF]

Front Endocrinol (Lausanne), 2022
Zhu R, Zhou S, Xia L, Bao X.
europepmc   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source