Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]
, 2017 An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...
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Mental health spillovers and the Millennium Development Goals: The case of perinatal depression in Khayelitsha, South Africa [PDF]
, 2012 Mental illness currently ranks among the top ten causes of burden of disease in low-income countries. In the African region specifically, neuropsychiatric disorders account for approximately 5% of disability-adjusted life years lost, with nearly one ...
Tomlinson, Mark, Tsai, Alexander C.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Congenital Toxoplasmosis in Austria: Prenatal Screening for Prevention is Cost-Saving [PDF]
, 2017 Background: Primary infection of Toxoplasma gondii during pregnancy can be transmitted to the unborn child and may have serious consequences, including retinochoroiditis, hydrocephaly, cerebral calcifications, encephalitis, splenomegaly, hearing loss ...
Hayde, Michael +5 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The persistence of very low correlations between NIH research funding and disease burdens
Public Health in PracticeObjectives: The degree to which the allocation of disease-specific research funding by the NIH is proportional to disease burden is an important question.
Ashley J.R. Carter, Milena Gevorkian
doaj +1 more source
Gender differences in premature mortality for cardiovascular disease in India, 2017–18
BMC Public Health, 2023 Background The present study tries to provide a comprehensive estimate of gender differences in the years of life lost due to CVD across the major states of India during 2017–18. Methods The information on the CVD related data were collected from medical
Jhumki Kundu +3 more
doaj +1 more source
Death Rate as a Demo-economic Factor of the Country's Labour Potential Reduction [PDF]
, 2016 The article deals with the impact of mortality rate on the reduction of labour potential. The authors determine the index of years of potential life lost, analyze the primary causes of deaths as well as provide some prognostic estimates concerning the ...
Kobelia, Z. (Zoryana) +2 more
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Continuing social presence of the dead: Exploring suicide bereavement through online memorialisation [PDF]
, 2014 © 2014 The Author(s). The last 10 years have seen a rise in Internet sites commemorating those lost to suicide. These sites describe the life of the deceased and the afterlife of relatives, parents, friends or siblings who have been termed the "forgotten
Bailey, Louis, Bell, Jo, Kennedy, David
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FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source