Results 31 to 40 of about 321,189 (288)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Yellow fever [PDF]

Revista da Associação Médica Brasileira, 2017
Bacha, Helio Arthur, Johanson, Gustavo Henrique   +1 more
  +9 more sources

Yellow Fever in Nigeria: A Review of Past, Current, and Future Strides

The Proceedings of the Nigerian Academy of Science, 2022
Since 1985, there has been resurgence of yellow fever in Africa with outbreaks occurring in more than 33 countries. From that time, thousands of cases have occurred in Nigeria which is the most populous country in Africa.
Anyebe B. Onoja, Temitope O. C. Faleye, Johnson A. Adeniji,, Rosemary A. Audu, Sunday A. Omilabu, Babatunde L. Salako   +5 more
doaj   +1 more source

Yellow Fever in Africa: Estimating the Burden of Disease and Impact of Mass Vaccination from Outbreak and Serological Data [PDF]

, 2014
Background:Yellow fever is a vector-borne disease affecting humans and non-human primates in tropical areas of Africa and South America. While eradication is not feasible due to the wildlife reservoir, large scale vaccination activities in Africa during ...
Burke, D, De La Hoz, F, Ferguson, NM, Garske, T, Grenfell, B, Hansen, PM, Hutubessy, R, Lewis, RF, Perea, W, Ronveaux, O, Staples, JE, Van Kerkhove, MD, Yactayo, S   +12 more
core   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Continuous Circulation of Yellow Fever among Rural Populations in the Central African Republic

Viruses, 2022
Yellow fever remains a public-health threat in remote regions of Africa. Here, we report the identification and genetic characterisation of one yellow-fever case observed during the investigation of a cluster of nine suspected haemorrhagic fever cases in
Huguette SIMO TCHETGNA, Stéphane DESCORPS-DECLERE, Benjamin SELEKON, Sandra GARBA-OUANGOLE, Xavier KONAMNA, Mathieu SOUNGOUZA, Gaspard TEKPA, Pierre SOMSE, Emmanuel NAKOUNE, Nicolas BERTHET   +9 more
doaj   +1 more source

Enrollment in YFV Vaccine Trial: An Evaluation of Recruitment Outcomes Associated with a Randomized Controlled Double-Blind Trial of a Live Attenuated Yellow Fever Vaccine

, 2013
This investigation evaluated several factors associated with diverse participant enrollment of a clinical trial assessing safety, immunogenicity, and comparative viremia associated with administration of 17-D live, attenuated yellow fever vaccine given ...
Edupuganti, Srilatha, Frew, Paula M., Keyserling, Harry L., Lu, Lu, Mulligan, Mark J., Shapiro, Eve T.   +5 more
core   +1 more source

The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study. [PDF]

, 2015
BACKGROUND: There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx.
A Roca, AB Sabin, Abdoulie Bojang, Anna Roca, B Pulendran, B Simell, Beate Kampmann, BM Gray, Brian Greenwood, Christian Bottomley, CP Farrington, D Waters, Ebenezer Foster-Nyarko, F Shann, F Shann, FE Harrell, H Faden, IG Ovsyannikova, KL O’Brien, Martin Antonio, Ousainou Darboe, P Aaby, PC Hill, PC Hill, PE Fine, Peter G Smith, S Greenland, Umberto D’Alessandro   +27 more
core   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source