Results 91 to 100 of about 951,374 (223)
African swine fever (ASF) is a highly contagious and lethal viral disease of swine. Therefore, it is urgent to develop a safe and effective vaccine. We constructed a live‐attenuated ASF vaccine bearing 24 gene deletions in 3 independent regions, ASFV‐Δ24.
Fan Xu +8 more
wiley +1 more source
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
Yellow Fever Vaccine; Recommendations of the Advisory Committee on Immunization Practices (ACIP) [PDF]
"This report updates CDC's recommendations for using yellow fever (YF) vaccine (CDC. Yellow fever vaccine: recommendations of the Advisory Committee on Immunizations Practices: MMWR 2002;51[No. RR-17]).
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The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud +12 more
wiley +1 more source
Vaccines licensed and in clinical trials for the prevention of dengue
Dengue has become a major global public health threat with almost half of the world's population living in at-risk areas. Vaccination would likely represent an effective strategy for the management of dengue disease in endemic regions, however to date ...
J. Torresi, G. Ebert, M. Pellegrini
doaj +1 more source
Introduction:The strategy to Eliminate Yellow Fever Epidemics (EYE) is a global initiative that includes all countries with risk of yellow fever (YF) virus transmission.
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Real, perceived and unknown adverse events secondary to vaccinations are a source of concern for care providers of children. In the USA large linked databases have provided helpful information regarding the safety of vaccines.
Ali, Mohammad +7 more
core +1 more source
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du +9 more
wiley +1 more source
United States Designated Yellow Fever Vaccination Centers [PDF]
Lists the city and state locations of all U.S. Designated Yellow Fever Vaccination Centers."This publication supersedes the Suppl.ement - U.S. Designated Yellow Fever Vaccination Centers, MMWR Weekly Report, Vol. 18, No.
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Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou +11 more
wiley +1 more source

