Results 111 to 120 of about 951,374 (223)
Decoding neurodevelopment risks of exposures to intoxication, infection, and trauma during pregnancy
Abstract The maternal environment plays a pivotal role in fetal neurodevelopment, but adverse conditions during pregnancy may disrupt key developmental processes. Conditions such as intoxication, infection, or trauma during pregnancy have been associated with impaired fetal oxygenation, altered immune signaling, and disrupted placental function, which ...
Brenda E. Lujan +7 more
wiley +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
The bio‐guided phytochemical study resulted in the new compound 17‐epi‐melianodiol. The compound eliminated 100% of Aedes aegypti larvae at 100 ppm, causing pronounced morphological changes, cuticular damage, and extensive vacuolization. Abstract BACKGROUND In Brazil, Aedes aegypti is the primary vector of arboviruses such as dengue, chikungunya ...
Kethleen Duarte Crespo Soares +8 more
wiley +1 more source
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria +5 more
wiley +1 more source
Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis +8 more
wiley +1 more source
Climate Informed Dengue Prediction and Future Risk Under a Changing Monsoon Climate in Kerala, India
Abstract Dengue fever has emerged as a major public health threat in India, with its burden projected to rise under climate change. This study investigates the influence of climate variability on dengue incidence in Kerala, a dengue hotspot in southern India, using 14 years of climate and dengue data (2006–2019).
Yacob Sophia +5 more
wiley +1 more source
Pulmonary Complications in Fatal Yellow Fever, Brazil, 2017–2019
Yellow fever (YF) mainly causes severe hepatitis; data on pulmonary pathology remain limited. We investigated respiratory tract pathology in 73 fatal YF cases during the 2017–2019 epidemic in São Paulo, Brazil.
Amaro N. Duarte-Neto +16 more
doaj +1 more source
The changing epidemiology of yellow fever and continued reports of rare but serious adverse events associated with yellow fever vaccine have drawn attention to the need to revisit criteria for the designation of areas with risk for yellow fever virus ...
Wilder-Smith, Annelies +21 more
core +1 more source
Mapping the Altered Landscape of TCR Repertoire in Autoimmune Diseases
ABSTRACT Autoimmune diseases arise from the breakdown of immune tolerance through complex interactions between genetic predisposition, environmental exposures, and adaptive immune responses. High‐throughput T‐cell receptor (TCR) repertoire sequencing has transformed our ability to characterize these responses, providing unprecedented insights into ...
Celine Albalaa +3 more
wiley +1 more source
ABSTRACT Background Live bird markets (LBMs) are high‐risk environments for the amplification and transmission of avian influenza viruses (AIVs). In Cambodia, limited data exist on knowledge, attitudes, and practices (KAP) among poultry workers, who represent a key occupational risk group.
Malen Chan +7 more
wiley +1 more source

