Vaccines for yellow fever disease: A narrative review [PDF]
Microbes and Infectious DiseasesBackground: Yellow fever is a severe and often fatal illness caused by Flavivirus. Yellow fever is endemic in tropical and subtropical regions of South America and Africa.
Sumira Malik +9 more
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The thermal stability of yellow fever vaccines [PDF]
Memórias do Instituto Oswaldo Cruz, 1990 The assessment of yellow fever vaccine thermostability both in lyophilized form and after reconstitution were analyzed. Two commercial yellow fever vaccines were assayed for their thermal stability. Vaccines were exposed to test temperatures in the range of 8 degrees C to 45 degrees C.
ISHAK, Ricardo, HOWARD, Colin R.
openaire +6 more sources
Visualization of yellow fever virus infection in mice using a bioluminescent reporter virus
Emerging Microbes and Infections, 2021 Yellow fever virus (YFV) is a re-emerging flavivirus, which can lead to severe clinical manifestations and high mortality, with no specific antiviral therapies available.
Hao-Long Dong +9 more
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Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones [PDF]
eLife 2020;9:e53704 (2020), 2019 The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Previous studies show that secondary responses to the yellow fever vaccine - the model for acute infection in humans - are weaker than primary ones, but only quantitative measurements can describe the concentration changes and lineage fates ...
arxiv +1 more source
Precise tracking of vaccine-responding T-cell clones reveals convergent and personalized response in identical twins [PDF]
PNAS 2018; 115 (50) 12704-12709, 2018 T-cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from longitudinal repertoire data.
arxiv +1 more source
Yellow Fever Virus Vaccine–associated Deaths in Young Women
Emerging Infectious Diseases, 2011 Yellow fever vaccine–associated viscerotropic disease is a rare sequela of live-attenuated virus vaccine. Elderly persons and persons who have had thymectomies have increased susceptibility.
Stephen J. Seligman
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Inferring the immune response from repertoire sequencing [PDF]
PLoS Comput Biol 16(4): e1007873 (2020), 2019 High-throughput sequencing of B- and T-cell receptors makes it possible to track immune repertoires across time, in different tissues, and in acute and chronic diseases or in healthy individuals. However, quantitative comparison between repertoires is confounded by variability in the read count of each receptor clonotype due to sampling, library ...
arxiv +1 more source
Detecting T-cell receptors involved in immune responses from single repertoire snapshots [PDF]
PLoS Biol 17(6): e3000314 (2019), 2018 Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires (RepSeq) produces huge datasets of T-cell receptor sequences from blood and tissue samples.
arxiv +1 more source
A mathematically assisted reconstruction of the initial focus of the yellow fever outbreak in Buenos Aires (1871) [PDF]
Papers in Physics 5, 050002 (2013), 2014 We discuss the historic mortality record corresponding to the initial focus of the yellow fever epidemic outbreak registered in Buenos Aires during the year 1871 as compared to simulations of a stochastic population dynamics model. This model incorporates the biology of the urban vector of yellow fever, the mosquito Aedes aegypti, the stages of the ...
arxiv +1 more source
Lineage-Specific Real-Time RT-PCR for Yellow Fever Virus Outbreak Surveillance, Brazil
Emerging Infectious Diseases, 2017 The current yellow fever outbreak in Brazil prompted widespread yellow fever virus (YFV) vaccination campaigns, imposing a responsibility to distinguish between vaccine- and wild-type YFV-associated disease. We developed novel multiplex real-time reverse
Carlo Fischer +14 more
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