Results 51 to 60 of about 33,608 (178)

Early IFN-gamma production after YF 17D vaccine virus immunization in mice and its association with adaptive immune responses. [PDF]

PLoS ONE, 2013
Yellow Fever vaccine is one of the most efficacious human vaccines ever made. The vaccine (YF 17D) virus induces polyvalent immune responses, with a mixed TH1/TH2 CD4(+) cell profile, which results in robust T CD8(+) responses and high titers of ...
Patrícia C C Neves, Juliana R Santos, Luciana N Tubarão, Myrna C Bonaldo, Ricardo Galler   +4 more
doaj   +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Estimating the historical impact of outbreak response immunisation programmes across 210 outbreaks in low and middle-income countries

BMJ Global Health
Background Outbreaks of vaccine-preventable diseases frequently occur in low and middle-income countries (LMICs), requiring outbreak response immunisation (ORI) programmes for containment.
Stefanie Vaccher, Romesh G Abeysuriya, Nick Scott, Dominic Delport, Tewodaj Mengistu, Alina M Muellenmeister, Gabrielle MacKechnie, Dan Hogan   +7 more
doaj   +1 more source

Single shot of 17D vaccine may not confer life-long protection against yellow fever

Memorias do Instituto Oswaldo Cruz, 2017
The yellow fever (YF) vaccine has been used since the 1930s to prevent YF, which is a severe infectious disease caused by the yellow fever virus (YFV), and mainly transmitted by Culicidae mosquitoes from the genera Aedes and Haemagogus .
Pedro FC Vasconcelos
doaj   +1 more source

Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil

Insect Molecular Biology, EarlyView.
Aedes aegypti females were significantly repelled by both volatile DEET and citronella oil in comparison to control (ethanol‐exposed) mosquitoes. Global gene expression changes were largest in the mosquito mouthparts, with notable downregulation of the three subunits comprising the mosquito CO2 receptor (Gr1, 2 and 3).
Ivan Drahun, Jessica M. Sparrow, Cody W. Koloski, Bryan J. Cassone   +3 more
wiley   +1 more source

A Review of Nonsteroidal Anti‐Inflammatory Drugs for Food‐Producing Animals With a Focus on Potential Applications for Farmed Finfish

Journal of Fish Diseases, EarlyView.
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English, Christine Huynh, William Roy, James W. Wynne, Hamish Rodger   +4 more
wiley   +1 more source

Estimating the number of unvaccinated Chinese workers against yellow fever in Angola

BMC Infectious Diseases, 2018
Background A yellow fever epidemic occurred in Angola in 2016 with 884 laboratory confirmed cases and 373 deaths. Eleven unvaccinated Chinese nationals working in Angola were also infected and imported the disease to China, thereby presenting the first ...
A. Wilder-Smith, E. Massad
doaj   +1 more source

Health and Survival Impacts of Early Childhood Development Programmes: The Case of the Happy Child Programme in Brazil

Review of Development Economics, EarlyView.
ABSTRACT This paper adds to the growing evidence on the impacts of early childhood development (ECD) programming by examining one of the world's largest home visitation programmes, the Happy Child Programme in Brazil, and its impacts on child vaccination and preventable death rates.
Raquel Tebaldi, Franziska Gassmann, Bruno Martorano   +2 more
wiley   +1 more source

Experimental DNA-Launched Live-Attenuated Vaccines Against Yellow Fever

Эпидемиология и вакцинопрофилактика, 2019
Background DNA-launched vaccine is “manufactured” in vaccinated individuals and does not require traditional vaccine manufacturing facility and technology. Goals.
P. Pushko, А. А. Ishmukhametov, P. P. Bredenbeek, I. S. Lukashevich   +3 more
doaj   +1 more source

Eco‐Epidemiological Study of Seropositivity Against Rickettsia and Leptospira Agents in Rural Areas of Urabá, Colombia

Tropical Medicine &International Health, EarlyView.
ABSTRACT Introduction Rickettsioses and leptospirosis are infectious diseases often underdiagnosed due to limited knowledge about their epidemiology, pathophysiology, and clinical aspects. Objectives To characterize the seroprevalence and seroincidence of Rickettsia and Leptospira agents and determine their associated factors in rural areas of Urabá ...
Mariana Torres‐Bustamante, Omar Cantillo‐Barraza, Albert I. Ko, Elsio A. Wunder Jr, Juan C. Quintero‐Vélez   +4 more
wiley   +1 more source