Results 71 to 80 of about 66,826 (220)

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Behavioural and fitness effects of experimental immune activation during incubation in a wild passerine

Ibis, EarlyView.
Incubation is vital for avian embryo development but demands significant parental investment, potentially at the cost of self‐maintenance and immune function. For example, the acute phase response (APR), a systemic reaction against inflammation, infection or tissue injury, can trigger sickness behaviours such as reduced activity and foraging.
Isabel Barreda, Marina García‐del Río, Santiago Merino, Manuel Fuertes‐Recuero, Alejandro Cantarero   +4 more
wiley   +1 more source

A Concept Analysis of Expertise Associated With Practicing Clinical Nurses in Hospital Settings

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim Analyse the concept of expertise among practicing clinical nurses in hospital settings. Background The generational loss of expert clinical nurses was exacerbated globally by the novel coronavirus. This ongoing loss combined with the increased complexity of hospitalised patients has prompted an urgent need to understand expertise among ...
Jonathan D. Hecht, Elizabeth M. Heitkemper, Valerie Danesh, Angela P. Clark, Linda H. Yoder   +4 more
wiley   +1 more source

Yellow Fever Virus Vaccine–associated Deaths in Young Women

Emerging Infectious Diseases, 2011
Yellow fever vaccine–associated viscerotropic disease is a rare sequela of live-attenuated virus vaccine. Elderly persons and persons who have had thymectomies have increased susceptibility.
Stephen J. Seligman
doaj   +1 more source

Yellow fever virus: historical and current issues regarding recent epidemics and vaccination in Brazil

Human Vaccines & Immunotherapeutics, 2020
Yellow fever has been recently described in nonurban areas of Brazil despite 80 years of commercial vaccine use. Although the disease does not spread fear in the general population as it did in the past, yellow fever virus continues to cause many cases ...
Ricardo Ishak, Marluísa de Oliveira Guimarães Ishak, Antonio Carlos R. Vallinoto, Francisco De Paula Pinheiro   +3 more
doaj   +1 more source

Engineered human immunoglobulin anti-yellow fever virus monoclonal antibodies to treat severe yellow fever

Journal of Travel Medicine, 2020
Teaser A new engineered human immunoglobulin (Ig)G anti-yellow fever virus monoclonal antibody suggested potential clinical benefit in Phase 1a and 1b clinical trial.
openaire   +2 more sources

Current Trends, Future Prospects and Constraints of Whole Microalgae and Their Fractions as a Functional Feed Ingredient for Animals

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Microalgae are a highly diverse group of unicellular organisms that grow in a wide range of aquatic environments and are widely used as dietary supplements for both human and animal applications. Microalgae are rich in lipids, proteins, carbohydrates and other valuable bioactive components such as pigments, antioxidants and vitamins.
Sietse Jan Koopmans, Simon Roques, Edoardo Zaccaria, Annemarie Mens, Soumya Kanti Kar   +4 more
wiley   +1 more source

Lineage-Specific Real-Time RT-PCR for Yellow Fever Virus Outbreak Surveillance, Brazil

Emerging Infectious Diseases, 2017
The current yellow fever outbreak in Brazil prompted widespread yellow fever virus (YFV) vaccination campaigns, imposing a responsibility to distinguish between vaccine- and wild-type YFV-associated disease. We developed novel multiplex real-time reverse
Carlo Fischer, Maria C. Torres, Pranav Patel, Andres Moreira-Soto, Ernest A. Gould, Rémi N. Charrel, Xavier de Lamballerie, Rita Maria Ribeiro Nogueira, Patricia C. Sequeira, Cintia D.S. Rodrigues, Beate M. Kümmerer, Christian Drosten, Olfert Landt, Ana Maria Bispo de Filippis, Jan Felix Drexler   +14 more
doaj   +1 more source

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

Medical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan, Andrew Hemphill, S. H. P. Parakrama Karunaratne, Arunasalam Naguleswaran, Isabel Roditi, Sinnathamby N. Surendran, Ranjan Ramasamy   +6 more
wiley   +1 more source

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Journal of Infection and Public Health, 2016
Summary: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
Raymond Taylor, Pravin Kotian, Travis Warren, Rekha Panchal, Sina Bavari, Justin Julander, Sylvia Dobo, Angela Rose, Yahya El-Kattan, Brian Taubenheim, Yarlagadda Babu, William P. Sheridan   +11 more
doaj   +1 more source