Results 61 to 70 of about 581,288 (313)

Spatial–temporal evolution of economic-ecological benefits and their driving factors in Yellow River irrigation areas

Ecological Indicators
Understanding the spatial–temporal variations in the economic-ecological benefits and driving factors within the Yellow River irrigation areas (YRIA) is crucial for ensuring high-quality socioeconomic development and ecological environment health of the ...
Chang Liu, Enhui Jiang, Bo Qu, Lingqi Li, Lingang Hao, Wei Zhang   +5 more
doaj   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Seasonal biological social and cognitive mechanisms of mental health among Chinese adolescents

Scientific Reports
This study develops a “Bio-Social-Cognitive Dynamic Interaction Model” to explore seasonal mental health risks in Chinese adolescents. Using data from cross-sectional surveys (N = 6,121), longitudinal tracking (N = 1,000), and RCTs (N = 200), we assess ...
Ran Chai, Jiaxiang Guo, Yue Geng, Xinding Yao   +3 more
doaj   +1 more source

Risk analysis of water resources carrying capacity based on a novel early warning framework

Environmental and Sustainability Indicators
Water Resources Carrying Capacity (WRCC) embodies the fundamental constraint relationship between water resource sustainability and regional economic growth as well as social development, serving as a key indicator for assessing regional sustainable ...
Heyuan Zhou, Xinwei Guo, Suzhen Dang, Chengpeng Lu   +3 more
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Emergy analysis of ecological water resources in Tarim river tail region

MATEC Web of Conferences, 2018
The lower reaches of the Tarim River (Chala-Taitma Lake) is a typical ecologically fragile and sensitive area in the arid river basin. By 2017, 17 ecological water conveyances have been continuously implemented in this area, and the accumulated ...
Zhang Xiangping, Wang Yuanjian, Jiang Enhui, Li Junhua   +3 more
doaj   +1 more source

Geochemistry of reduced inorganic sulfur, reactive iron, and organic carbon in fluvial and marine surface sediment in the Laizhou Bay region, China [PDF]

, 2015
Understanding the geochemical cycling of sulfur in sediments is important because it can have implications for both modern environments (e.g., deterioration of water quality) and interpretation of the ancient past (e.g., sediment C/S ratios can be used ...
Bottrell, S, Mortimer, R, Sheng, Y, Shi, W, Sun, Q   +4 more
core   +2 more sources

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Prediction of Sediment Yield in the Middle Reaches of the Yellow River Basin Under Extreme Precipitation

Frontiers in Earth Science, 2020
The Yellow River is one of the rivers with the largest amount of sediment in the world. The amount of incoming sediment has an important impact on water resources management, sediment regulation schemes, and the construction of water conservancy projects.
Suzhen Dang, Suzhen Dang, Xiaoyan Liu, Huijuan Yin, Huijuan Yin, Xinwei Guo, Xinwei Guo   +6 more
doaj   +1 more source