Results 71 to 80 of about 581,288 (313)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Can water allocation in the Yellow River basin be improved?: Insights from a multi-agent system model [PDF]

In 1999, the Government of China enforced a cross-provincial, quota-based Water Allocation Agreement that was developed in 1987 and titled Unified Water Flow Regulation (UWFR) to ensure that flow to the Yellow River mouth would not be cut off.
Cai, Ximing, Ringler, Claudia, Yang, Yi-Chen E., Zhao, Jianshi   +3 more
core  

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Underground Defects Detection Based on GPR by Fusing Simple Linear Iterative Clustering Phash (SLIC-Phash) and Convolutional Block Attention Module (CBAM)-YOLOv8

IEEE Access
Ground Penetrating Radar (GPR) is an effective non-destructive detection method, that is frequently utilized in the detection of urban underground defects because of its quick speed, convenient and flexible operation, and high resolution.
Niannian Wang, Zexi Zhang, Haobang Hu, Bin Li, Jianwei Lei   +4 more
doaj   +1 more source

Water management reforms in the Yellow River Basin: implications for water savings, farm incomes and poverty [PDF]

River basins / Water management / Governance / Water use / Crop production / Models / Farm income / Poverty / Water users’ associations / China / Yellow River ...
Biltonen, Eric, Huang, J., Hussain, Intizar, Rozelle, S., Wang, J., Xu, Z.   +5 more
core  

Study of Sanmenxia Dam Effects on Backwater and Human Activities in Middle Yellow River, China [PDF]

, 2007
The study aimed to investigate Sanmenxia Dam effects on backwater and human activities in middle Yellow River through proposed models combined with statistical model, Backward Propagation Artificial Neural Network (BP-ANN) model, and hydrodynamic ...
He, Hongming
core   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Synergistic relationships among water resources, ecological environment, and social economy in the Lower Yellow River

Applied Water Science
The Lower Yellow River (LYR) is short of water resources. The imbalance and incoordination of water resources (WR), ecological environment (EE) and social economy (SE) have become the key constraints of regional sustainable development.
Yuhang Bian, Bo Qu, Enhui Jiang, Ying Liu, Lingang Hao, Hailong Wei   +5 more
doaj   +1 more source