Results 151 to 160 of about 778 (189)

Toxicology of the Yessotoxins

2008
This chapter reviews existing data regarding the toxicity of yessotoxina administered by different routes in animal models.
R. Munday, T. Aune, ROSSINI, Gian Paolo
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Toxicologic evaluation of Yessotoxin

Natural Toxins, 1997
Yessotoxin (YTX), originally found in association with diarrhetic shellfish poisoning (DSP), caused neither intestinal fluid accumulation nor inhibition of protein phosphatase 2A. Orally, YTX was not lethal to mice at 1.0 mg/kg. The toxin showed weak cytotoxic and antifungal activities. Neither hemolytic nor ichthyotoxic effect was observed.
H, Ogino, M, Kumagai, T, Yasumoto
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High levels of yessotoxin in mussels and presence of yessotoxin and homoyessotoxin in dinoflagellates of the Adriatic Sea

Toxicon, 1999
Identification of YTX and homoYTX in natural phytoplankton populations containing significant amounts of Gonyaulax polyedra and determination of detailed toxin profiles of mussels (Mytilus galloprovincialis) periodically collected from two sites of the Northern Adriatic coast from February to October 1997 was performed by LC-FLD following ...
R, Draisci, E, Ferretti, L, Palleschi, C, Marchiafava, R, Poletti, A, Milandri, A, Ceredi, M, Pompei   +7 more
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Yessotoxin in mussels of the northern Adriatic Sea

Toxicon, 1997
This study investigated the composition of diarrhoetic shellfish toxins in the hepatopancreas of mussels from the northern Adriatic Sea. The major toxins were shown to be yessotoxin, identified by its chromatographic properties and spectral data, and okadaic acid, detected both by fluorometric high-performance liquid chromatography and by comparison of
CIMINIELLO, PATRIZIA, FATTORUSSO, ERNESTO, FORINO, MARTINO, S. MAGNO, R. POLETTI, M. SATAKE, R. VIVIANI, T. YASUMOTO   +7 more
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Convergent synthesis of the FGHI ring segment of yessotoxin

Tetrahedron Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Yoshinori Yamamoto, Isao Kadota
exaly   +2 more sources

Structure−Activity Relationships of Yessotoxins in Cultured Cells

Chemical Research in Toxicology, 2004
The structure-activity relationship of yessotoxins (YTX) has been probed by measuring the potency of several YTX analogues to cause the accumulation of a 100 kDa MW fragment of E-cadherin in MCF-7 breast cancer cells. Under our experimental conditions, the EC(50) of YTX, the reference compound, was 0.55 nM. The introduction of a methylene unit adjacent
S. FERRARI S, CIMINIELLO, PATRIZIA, DELL'AVERSANO, CARMELA, FORINO, MARTINO, C. MALAGUTI, A. TUBARO, R. POLETTI, T. YASUMOTO, FATTORUSSO, ERNESTO, G. P. ROSSINI   +9 more
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Yessotoxins and Pectenotoxins

2014
Yessotoxin (YTX) and its analogs are a group of more than 100 polyether compounds produced by several species of dinoflagellates genera Gonyaulax, Protoceratium, and Lingulodinium and originally isolated from Patinopecten yessoensis. Some effect of YTX over protein kinase C translocation was reported in primary cortical neurons. YTXs often coexist with
Amparo Alfonso, Araceli Tobío, M. Carmen Louzao   +2 more
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Immunolocalization of yessotoxins in the mussel Mytilus galloprovincialis

Toxicon, 2003
This study reports, for the first time, immunocytochemical evidence of the distribution of algal yessotoxins (YTXs) in the mussel Mytilus galloprovincialis. Immunopositivity to YTXs was found in immunocytes and in the digestive gland. With regards the gland, the positivity was mainly present in the lumen of both tubules and ducts. No YTXs were detected
FRANCHINI, Antonella, A. Milandri, R. Poletti, OTTAVIANI, Enzo   +3 more
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Subacute immunotoxicity of the marine phycotoxin yessotoxin in rats

Toxicon, 2017
Yessotoxin (YTX) is a marine phycotoxin produced by dinoflagellates and accumulated in filter feeding shellfish. YTX content in shellfish is regulated by many food safety authorities to protect human health, although currently no human intoxication episodes have been unequivocally related to YTX presence in food.
Sara F. Ferreiro, Natalia Vilariño, Cristina Carrera, M. Carmen Louzao, Germán Santamarina, Antonio G. Cantalapiedra, J. Manuel Cifuentes, Andrés C. Vieira, Luis M. Botana   +8 more
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Convergent synthesis of the A–F ring segment of yessotoxin and adriatoxin

Tetrahedron Letters, 2003
Abstract A convergent synthesis of the A–F ring segment of yessotoxin and adriatoxin was achieved via the intramolecular allylation of an α-chloroacetoxy ether and subsequent ring-closing metathesis.
Yoshinori Yamamoto, Isao Kadota
exaly   +2 more sources