Results 161 to 170 of about 778 (189)

Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice

Toxicon, 2002
Currently, yessotoxin is regulated among the toxins in the diarrhetic shellfish poisoning (DSP) complex. Yessotoxin is equally acutely toxic towards mice upon intraperitoneal injections as those algal toxins giving diarrhea, but is not diarrheagenic.
T Landsverk, T Yasumoto, T Aune
exaly   +3 more sources

Paraptosis-like cell death induced by yessotoxin

Toxicology in Vitro, 2011
This study shows that BC3H1 myoblast cell lines exposed to 100 nM yessotoxin (YTX) undergo a form of programmed cell death distinct from apoptosis and with features resembling paraptosis. Morphologically, cells treated with YTX reveal extensive cytoplasmic vacuolation, mitochondrial and endoplasmic reticulum swelling, uncondensed chromatin and ...
Mónica Suárez, Korsnes, Arild, Espenes, Dyveke Lem, Hetland, Lene C, Hermansen   +3 more
openaire   +2 more sources

Molecular Bases of Effects of Azaspiracids and Yessotoxins

2014
None
ROSSINI, Gian Paolo, SALA, GIAN LUCA
openaire   +2 more sources

Effects of yessotoxin (YTX) on the skeletal muscle: an update

Food Additives & Contaminants: Part A, 2008
Yessotoxins (YTXs) are algal toxins originally included in the diarrheic toxins. After oral intake, YTXs induce only ultra-structural changes (packages of swollen mitochondria) in cardiac cells. The aim of this study was to investigate the possible effects of YTX on the other contractile striated tissue, the skeletal muscle, in vitro and in vivo.
TUBARO, AURELIA, BANDI, ELENA, SOSA, SILVIO, SORANZO, MARIA ROSA, GIANGASPERO, ANNA, DE NINIS V, YASUMOTO T, LORENZON, Paola   +7 more
openaire   +3 more sources

Effect of mouse strain and gender on LD50 of yessotoxin

Toxicon, 2008
The aim of the present study was to determine whether the intraperitoneal LD(50) for yessotoxin (YTX) in mice varies with strain or gender. Thirty-six male and 36 female mice, of body weight 16-20 g, from each of the strains ICR (CD-1), Swiss (CFW-1) and NMRI were employed. They were not fasted before YTX treatment.
Tore, Aune, John A B, Aasen, Christopher O, Miles, Stig, Larsen   +3 more
openaire   +2 more sources

Polyhydroxylated amide analogs of yessotoxin from Protoceratium reticulatum

Toxicon, 2005
Two analogs of yessotoxin were isolated from extracts of a culture of Protoceratium reticulatum. The structures of the analogs were identified as trihydroxylated amides of 41a-homoyessotoxin (1) and 9-methyl-41a-homoyessotoxin (2) by one- and two-dimensional 1H and 13C NMR spectroscopy and LC-MS3 analyses.
Christopher O, Miles, Alistair L, Wilkins, Allan D, Hawkes, Andrew I, Selwood, Dwayne J, Jensen, Rex, Munday, Janine M, Cooney, Veronica, Beuzenberg   +7 more
openaire   +2 more sources

A slot blot procedure for the measurement of yessotoxins by a functional assay

Toxicon, 2007
We originally developed a functional assay for the detection of yessotoxins (YTX) based on its capacity to induce dose-dependent changes in cellular levels of two marker proteins, consisting of E-cadherin and an E-cadherin fragment (ECRA100) in epithelial cells.
Pierotti S, ALBANO, Clara, Milandri A, CALLEGARI, Federica, Poletti R, ROSSINI, Gian Paolo   +5 more
openaire   +3 more sources

Extraction and cleaning methods to detect yessotoxins in contaminated mussels

Analytical Biochemistry, 2007
Yessotoxin (YTX) and its analogues are a newly recognized group of toxins with increased presence in shellfish in recent years. They can be quantified by various functional assays due to their interaction with phosphodiesterases (PDEs). One of these assays detects the binding between the YTX and the fluorescently labeled PDE I using fluorescence ...
C, Alfonso, A, Alfonso, M J, Pazos, M R, Vieytes, T, Yasumoto, A, Milandri, R, Poletti, L M, Botana   +7 more
openaire   +2 more sources

Identification of Protoceratium reticulatum as the biogenetic origin of yessotoxin

Natural Toxins, 1997
AbstractYessotoxin (YTX), a disulfated polyether toxin, was isolated from cultured cells of the marine dinoflagellate Protoceratium reticulatum and unambiguously identified by high‐performance liquid chromatography, 1H NMR, and MS data. The result is the first to confirm toxigenicity of this species and demonstrate it as one of the biogenetic origins ...
M, Satake, L, MacKenzie, T, Yasumoto
openaire   +2 more sources

A functional assay for yessotoxins

2003
This paper describes the properites of a cell-based assay for the detection and quantification of yessotoxin-group toxins contaminating shellfish extracts. The procedure exploits the property of yessotoxin to induce the accumulation of a 100 kDa fragment of E-cadherin in epithelial cells.
PIEROTTI S., FERRARI S., MALAGUTI C., MILANDRI A., POLETTI R., ROSSINI, Gian Paolo   +5 more
openaire   +1 more source