Results 191 to 200 of about 2,526,956 (308)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Evaluation of improved cassava genotypes for fresh root yield and yield components in demand creation trial. [PDF]

Front Plant Sci
Onyenali TC, Ogwuche TO, Onyeka J, Diebiru-Ojo EM, Ikechukwu I, Abah SP, Okwuonu I, Ameh EA, Sanni L, Kulakow AP, Egesi CN.   +10 more
europepmc   +1 more source

SSR Genotyping and Marker-Trait Association with Yield Components in a Kazakh Germplasm Collection of Chickpea (Cicer arietinum L.). [PDF]

Biomolecules, 2023
Mazkirat S, Baitarakova K, Kudaybergenov M, Babissekova D, Bastaubayeva S, Bulatova K, Shavrukov Y.   +6 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Combination of QTL mapping and GWAS for fine mapping and gene mining of drought tolerance and seed yield components in faba bean (Vicia faba L.). [PDF]

BMC Plant Biol
Gutierrez N, Torres AM.
europepmc   +1 more source

Yield components affected by rice black-streaked dwarf virus disease in rice cultivars with different resistance levels. [PDF]

Front Microbiol, 2023
Sun Y, Jing D, Zhang J, Du L, Li C, Lan Y, Lin F, Zhou T.   +7 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Using pelleted lateral buds of sugarcane stalk as seeds with an approach to improve sugarcane yield components. [PDF]

BMC Plant Biol
Ajribzadeh Z, Farzaneh S, Shomeili M, Balouchi H, Seyed Sharifi R.   +4 more
europepmc   +1 more source

Meta-QTL Analysis for Yield Components in Common Bean (Phaseolus vulgaris L.). [PDF]

Plants (Basel), 2022
Arriagada O, Arévalo B, Cabeza RA, Carrasco B, Schwember AR.   +4 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source