Results 221 to 230 of about 4,416,719 (302)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Integrated Metabolic, Oxidative, Inflammatory, and Mammary Health Signatures Characterize Low Body Condition Score in Dairy Cows. [PDF]

Int J Mol Sci
Puppel K, Slósarz J, Grodkowski G, Solarczyk P, Kostusiak P, Kunowska-Slósarz M, Tucki K, Młynek K, Balcerak M.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

DFT-assisted rational design of salan ligands for highly enantioselective Zr-salan-catalyzed hydroxylation of cyclic <i>β</i>-keto esters. [PDF]

Smart Mol
Ma C, Tang K, Jiang Y, Zhu H, Wu Y, Xing Y, Wang Y, Liu Q, Du J, Meng Q.   +9 more
europepmc   +1 more source

Evaluation of Yield and Yield Components of Maize in Conditions of Changing Climate

Acta fytotechnica et zootechnica
Joanna Korczyk-Szabó, Ľubomíra Hromadová, Milan Macák, Miroslav Habán   +3 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Differential Temperature Effects on Phenolic Recovery and Antioxidant Capacity During the Hydroethanolic Extraction of Chilean Blueberry Pomace. [PDF]

Antioxidants (Basel)
Espinoza-Cartagena F, Benítez-Fajardo M, Ormazábal-Latorre S, Cuellar LM, Sánchez-Baeza C, Núñez GA, Arroyo-Avirama AF.   +6 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Statement exhibiting the moral and material progress and condition of India during the year 1871-72

, 1873
East India (Progress and Condition)
core  

A method for calculating wetting collapse potential of loess based on basic physical indices. [PDF]

iScience
Fan X, Shao C, Wang H, Song M, Ren C, Li L.   +5 more
europepmc   +1 more source