Results 121 to 130 of about 1,794,891 (330)

High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii [PDF]

, 2016
Veerle E. T. Maervoet, Sofie De Maeseneire, Fatma Gizem Avcı, Joeri Beauprez, Wim Soetaert, Marjan De Mey   +5 more
openalex   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Metabolic engineering of Escherichia coli for the production of 5-aminolevulinic acid based on combined metabolic pathway modification and reporter-guided mutant selection (RGMS)

Biotechnology for Biofuels and Bioproducts
Background 5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields such as medicine, nutrition and agriculture.
Yuting Yang, Yuhong Zou, Xi Chen, Haidong Sun, Xia Hua, Lee Johnston, Xiangfang Zeng, Shiyan Qiao, Changchuan Ye   +8 more
doaj   +1 more source

Engineering microbiomes to enhance macroalgal health, biomass yield, and carbon sequestration

Green Carbon
Macroalgae farming not only holds significant economic value but also contributes substantially to carbon sequestration, and therefore has gained intensified attention globally under climate change scenarios.
Shailesh Nair, Zenghu Zhang, Xiaojie Wang, Bo Zhang, Nianzhi Jiao, Yongyu Zhang   +5 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An experimental study on the yield strength of cement grout for grouting in the limestone area of a coal seam floor

Meitian dizhi yu kantan
Objective and MethodsIn recent years, regional grouting through ground directional drilling has become the preferred technique for water disaster prevention and control in floor limestones in a coal mining area.
Jun ZOU, Yan GUO, Herong GUI, Weimin WANG, Zhenlin CHEN, Faming LIU, Yanan DAI, Yang HU, Zengbao CHEN, Jun LI, Chuan GAO, Heng LI   +11 more
doaj   +1 more source

An automated procedure for material parameter evaluation for viscoplastic constitutive models [PDF]

An automated procedure is presented for evaluating the material parameters in Walker's exponential viscoplastic constitutive model for metals at elevated temperature.
Allen, D. H., Haisler, W. E., Hill, P. S., Imbrie, P. K., James, G. H.   +4 more
core   +1 more source