Results 121 to 130 of about 6,259,448 (248)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Impacts of Heat Stress around Flowering on Growth and Development Dynamic of Maize (Zea mays L.) Ear and Yield Formation. [PDF]

Plants (Basel), 2022
Wang N, Liu Q, Ming B, Shang W, Zhao X, Wang X, Wang J, Zhang J, Luo Z, Liao Y.   +9 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Strengthening leaf physiological functioning and grain yield formation in heat-stressed wheat through potassium application. [PDF]

Front Plant Sci, 2022
Sarwar M, Saleem MF, Maqsood H, Ullah N, Khan A, Waqas M, Sattar N, Tasneem M, Xu X, Zhangli H, Shuang Y.   +10 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Grain-filling characteristics and yield formation of wheat in two different soil fertility fields in the Huang-Huai-Hai Plain. [PDF]

Front Plant Sci, 2022
Zheng X, Yu Z, Yu F, Shi Y.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Secteur de formation 9 : électrotechnique

, 2008
Titre de l'écran-titre (visionné le 21 août 2008)"Secteur de formation 9 ...
Huot, Benoit, Québec (Province). Formation professionnelle et technique et formation continue. Direction générale de la formation professionnelle et technique, Cloutier, Pierre,, Deschênes, Gilles   +3 more
core   +1 more source

Modeling Heteroskedasticity of Crop Yield Distributions: Implications for Normality [PDF]

The paper analyzes the extent to which ignorance of heteroskedasticity or its inadequate modeling would result in misleading statistical inferences about crop yield distribution.
Kapiamba, Luabeya F.
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source