Results 121 to 130 of about 41,970 (253)
(主査) 教授 今村 央, 教授 髙津 哲也, 准教授 John Richard Bower, 教授 松石 隆(国際食資源学院) 水産科学院(海洋生物資源科学専攻)
openaire
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Growth, mortality, and exploitation of <i>Saurida lessepsianus</i> Russell, Golani & Tikochinski, 2015, from a southern Aegean Sea small-scale fishery: a stock assessment for sustainable fisheries. [PDF]
Reis İ, Ateş C.
europepmc +1 more source
This paper discusses the conclusion of various IATTC stock assessment report on yellowfin that MSY of the longline fishery could be larger than 400000 t. in the EPO. Based on the analysis of fishery data and environmental data in the Pacific ocean and in the EPO, the paper reaches the conclusion that the real potential MSY of longliners on the EPO YFT ...
/Fonteneau, Alain, Ariz, J.
openaire +3 more sources
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Illuminating the genome: emerging approaches in CRISPR-Cas live-cell imaging. [PDF]
Xiao Z, Sun Y.
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
How Australia's social media minimum age law may reshape research recruitment for adolescents under 16. [PDF]
O'Dea B, McKenzie I, Torok M.
europepmc +1 more source

