Results 171 to 180 of about 41,970 (253)

Diagnostic yield of electroencephalographyin the emergency department: protocol for the EMINENCE-M multicentre retrospective observational study. [PDF]

BMJ Open
Scarpino M, Piccardi B, Nencioni A, Nazerian P, Lettieri F, Grassi E, Marra E, Mannini A, Maiorelli A, Liuzzi P, Grippo A, The Eminence Study Group.   +11 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Comparative Operational Performance of Baited Logs, Lure Traps, and Flight-Intercept Traps in a Province-Scale Surveillance Program for Pine Wood-Boring Beetles in Yunnan, Southwestern China. [PDF]

Insects
Liu J, Jiang Q, He S, Wu Z, Wu J, Ping T, Liu Y.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A Data-Driven Methodological Framework for Representative Recruitment in Psychiatric Research: Insights from the DOCUMENT Study

Gooddy BJM, Rida L, Mew BG, Moura AR, Szentgyorgyi T, Eiff B, Schalk L, Rafiq I, Davies C, Martins D, Porffy LA, Gibson C, Wooldridge C, Bergamini G, Nicholson JR, Waser M, Tunbridge E, Süssmuth SD, Janulczyk VR, Allebrandt KV, Hampshire A, Shergill SS, Williams S.   +22 more
europepmc   +1 more source

Medroxyprogesterone acetate vs. GnRH antagonist for preventing premature LH surge during ovarian stimulation in assisted reproductive technology: a retrospective cohort study. [PDF]

Front Reprod Health
Jimenez MM, Jesam C, Sequeira K, Alcantar K.   +3 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Screening of "Cry for Help" Signals from <i>Angelica sinensis</i> Induced by <i>Fusarium solani</i> and Their Potential for Biological Control. [PDF]

Metabolites
Xie T, Ding Q, Yang L, Wang J, Wei J, Du X, Jin L.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source