Results 131 to 140 of about 9,596,460 (344)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Rheological Properties of Heavy Crude Oil Containing Sand From Bo-Hai Oilfield in China

Applied Rheology, 2017
This paper presents an experimental study on the rheological properties of heavy crude oil containing sand to determine the effects of sand size distribution and mass concentration on apparent viscosity, thixotropic behavior, yield stress and ...
Zhang Dong, Liu Shuo, Zhang Jian, Xu Jing-yu   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Measurement Errors in Yield Stress Rheometry that Arise from Torque Auto Zero

Applied Rheology, 2006
The measurement of the shear rheology of concentrated particulate suspensions is important to a range of mixing, pumping and flow operations. The use of a four or six bladed vane attached to a rheometer in an open cup is a popular technique to achieve a ...
Fisher Daniel T., Boger David V., Scales Peter J.   +2 more
doaj   +1 more source

Dilatancy of cement slurries with chemical admixtures

Journal of Civil Engineering and Management, 2004
The results of experimental investigation of plasticising, air‐entraining and viscosity‐modifying admixtures with different chemical composition influence on rheological properties and dilatancy of cement slurries are presented in the article ...
Gintautas SkripkiÅ«nas, Mindaugas DaukÅ¡ys   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Consistency and Rheological Properties of Cemented Paste Backfills Prepared with Tailings with Varying Free Muscovite Content

Mining
The presence of free muscovite in tailings can negatively affect the mechanical strength and rheological properties of cemented paste backfill, as has been observed for several cementitious materials. The aim of this study is to evaluate the influence of
Hadj Ghani Menasria, Mamert Mbonimpa, Tikou Belem, Abdelkabir Maqsoud   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Channel Flow of a Tensorial Shear-Thinning Maxwell Model: Lattice Boltzmann Simulations

, 2013
We introduce a nonlinear generalized tensorial Maxwell-type constitutive equation to describe shear-thinning glass-forming fluids, motivated by a recent microscopic approach to the nonlinear rheology of colloidal suspensions.
Batchelor G. K., Bird R. B., Doi M., Larson R. G., Oswald P., S. Papenkort, Succi S., Th. Voigtmann   +7 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source