Results 141 to 150 of about 576,522 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Yield-stress transition in suspensions of deformable droplets. [PDF]

Sci Adv, 2023
Negro G, Carenza LN, Gonnella G, Mackay F, Morozov A, Marenduzzo D.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Foam coarsening in a yield stress fluid

Soft Matter
Foams made from emulsion show heterogeneous bubble organisation and growth during coarsening due to the continuous phase yield stress.
Alice Requier, Chiara Guidolin, Emmanuelle Rio, Nicolò Galvani, Sylvie Cohen-Addad, Olivier Pitois, Anniina Salonen   +6 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Phenotypic data of HIBAP I panel under yield potential and heat stress conditions

, 2022
Phenotypic data of HIBAP I panel evaluated under yield potential and heat stress conditions during Obregon wheat seasons 2015-16 and 2016-17. Combined data across years per environment.
Molero, Gemma, Pinto, Francisco, Joynson, Ryan, Rivera Amado, Alma Carolina, Reynolds, Matthew, Hall, Anthony, Piñera Chavez, Francisco Javier, Coombes, Benedict   +7 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Scaling Laws for Optimal Herschel–Bulkley Yield Stress Fluid Flow in Self-Similar Tree-like Branching Networks

This study analyzes optimal flow conditions and structures in tree-like branching networks for yield stress Herschel–Bulkley fluids. We focus on maximizing flow conductance under volume constraints, assuming fully developed laminar flow in circular tubes.
Ashish, Garg
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effectiveness of different phytohormones on grain filling and yield of rice (Oryza sativa L.) under drought stress [PDF]

, 2014
Drought is a major limiting factor affecting rice yield and productivity all over the world, including Malaysia. To induce drought resistance, there is an increasing interest in using different phytohormones for field crop production considering its ...
M. Robiul Islam,, Panhwar, Qurban Ali, Berahim, Zulkarami, Ismail, Mohd Razi, Mohd Saud, Halimi, Mondal, Mohd Monjurul Alam   +5 more
core