Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
BACKGROUND TO THE INTRODUCTION OF HIGH YIELDING VARIETIES OF RICE IN THAILAND [PDF]
This paper describes Thailand's experience to date with new technology in rice, namely new high yielding varieties with associated inputs, which forms one part of the "green revolution." First, the historical background in exports, production, and ...
Welsch, Delane E., Tongpan, Sopin
core
Jamming and yielding of dislocations: from crystal plasticity to superconducting vortex flow
We discuss the statistical properties of interacting dislocations in plastically deformed crystals. Due to their long-range mutual interactions, dislocations arrange into jammed configurations, that can be set into motion under the action of an external ...
M. Carmen Miguel +3 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
On the toughness of thermoplastic polymer nanocomposites as assessed by the essential work of fracture (EWF) approach [PDF]
The essential work of fracture (EWF) approach is widely used to determine the plane stress fracture toughness of highly ductile polymers and related systems.
Bárány, T. +4 more
core +1 more source
Blue honeysuckle due to the high health benefits of its fruit, early ripening (before the first strawberries cultivars) and high frost resistance of both plants and flowers has gained the great popularity both in cultivation and breeding.
Jacek Gawroński +5 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
GROWTH AND YIELDING OF SWEET CHERRY TREES GRAFTED ON NEW BIOTYPES OF Prunus mahaleb (L.)
In the years 2011–2013 growth and yielding of four cultivars of sweet cherry trees: Burlat’, ‘Regina’, ‘Summit’ and ‘Vanda’ were evaluated. All of them were grafted on new Mahaleb rootstocks obtained through softwood cuttings selected from a population ...
Aleksander Stachowiak +2 more
doaj
Effect of Particle Size and Cohesion on Powder Yielding and Flow
The bulk properties of powders depend on material characteristics and size of the primary particles. During storage and transportation processes in the powder processing industry, the material undergoes various modes of deformation and stress conditions,
Hao Shi +9 more
semanticscholar +1 more source

