Results 141 to 150 of about 164,502 (281)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Nomogram for predicting testicular yolk sac tumor in children based on age, alpha-fetoprotein, and ultrasonography

Frontiers in Pediatrics
ObjectiveTo establish a predictive model for distinguishing testicular benign or yolk sac tumors in children.MethodsWe retrospectively analyzed data for 119 consecutive patients with unilateral testicular tumors treated at a single institution from June ...
Huan Yu, Hui Wang, Yichen Huang, Huiyong Hu, Yue Zhang, Min Wu, Yiqing Lyu, Yan Chen, Lijun Zhou, Yan Liang, Huizhen Sun, Xiaoling Lin, Hua Xie, Fang Chen   +13 more
doaj   +1 more source

The Embryonic Development of the Cotylean Polyclad Phrikoceros jannetae

Acta Zoologica, EarlyView.
ABSTRACT Polyclads exhibit distinct developmental modes ranging from direct to indirect development, with several transitional stages also recognised. The existence of an indirect developmental mode in polyclads with a planktonic life history stage in the form of a free‐swimming larva is unique among all free‐living flatworms and makes polyclads a ...
Mehrez Gammoudi, Bernhard Egger, Isabel L. Dittmann, Verónica N. Bulnes, Pavel Tomancak, Abdel Halim Harrath, Johannes Girstmair   +6 more
wiley   +1 more source

Extragonadal yolk sac tumor outside of the midline of the body: a case report of a child with a yolk sac tumor of the pontocerebellar angle

, 2009
Yolk sac tumor is a rare germ cell neoplasm occurring mainly in the gonads. Extragonadal yolk sac tumor is a very rare malignancy; its main distribution is along the midline of the body at three principal sites: mediastinum, central nervous system and ...
Nadia Puma, Ilaria Lazzareschi, Riccardo Riccardi, Coccia, Paola, Furfaro, Ilaria Francesca Lucina, Ilaria Francesca Furfaro, Paola Coccia, Lazzareschi, Ilaria, Riccardi, Riccardo, Puma, Nadia   +9 more
core   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

Biophysical Factors Controlling Spatiotemporal Variability in Fishes' Early Life History Distribution in the Kattegat Ecosystem

Fisheries Oceanography, EarlyView.
ABSTRACT The Kattegat Sea acts as a nursery area for several fishes, exhibiting complex ichthyoplankton dynamics influenced by environmental factors and species‐specific traits. We investigated factors influencing spatiotemporal variability in yolk‐sac larvae presence and areal density for three economically and ecologically important fishes: sandeel ...
Kris‐Emil Mose Jørgensen, Peter Grønkjær, Anna B. Neuheimer   +2 more
wiley   +1 more source

Identifying the Drivers of Newfoundland Capelin Recruitment After a Breakdown in the Environment–Recruitment Relationship

Fisheries Oceanography, EarlyView.
ABSTRACT Environment‐recruitment relationships often break down over time. This can occur because of spurious results from testing numerous environmental variables in the original analyses or from relative changes in the importance of specific environmental drivers over time.
Hannah M. Murphy, Frédéric Cyr, Aaron T. Adamack, Dominique Robert, Pierre Pepin   +4 more
wiley   +1 more source

Mast Cells in Host Defense Against Cutaneous Staphylococcus aureus Infection

Immunology &Cell Biology, EarlyView.
Impact of S. aureus epicutaneous sensitization models on mast cell function in vivo. D. farinae and Staphylococcal enterotoxin B (SEB) activate Trpv1+ Tac1+ nociceptors to trigger the release of substance P (SP), which promotes mast cell degranulation through Mrgprb2. S.
Hannah Dychtenberg, Carly Kadonoff, Bailey Lehnert, Priyanka Pundir   +3 more
wiley   +1 more source