Results 161 to 170 of about 164,502 (281)
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Physiological and anatomical determinants of placental drug transfer
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source
ABSTRACT Pond‐based aquaculture demands effective management of dissolved oxygen (DO) for sustainable intensification to improve productivity. This study evaluated surface aeration (SA), bottom aeration (BA) and combined surface‐bottom aeration (SBA) against a non‐aerated control during a 120‐day monoculture of Nile tilapia (Oreochromis niloticus ...
Mithun Roy +10 more
wiley +1 more source
Comparative Performance of Kenyan and Imported Artemia in Early Larval Rearing of Clarias gariepinus
ABSTRACT Successful larval rearing of fish depends largely on live feed availability, during the critical first‐feeding stage. In Kenya, hatcheries commonly use phytoplankton or imported Artemia cysts as starter feeds, although locally produced Artemia is available. Hatchery operators' reports on low larval survival when using imported Artemia prompted
Morine M. Ngarari +9 more
wiley +1 more source
CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner +13 more
wiley +1 more source
Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar +3 more
wiley +1 more source
Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman +12 more
wiley +1 more source
Hydroxypropyl‐β‐cyclodextrin (HPβCD)–N,N‐diethyl‐meta‐toluamide (DEET) complex extended tick repellency to 168 h. Full protection against Aedes aegypti for 7 h with HPβCD‐DEET. HPβCD reduced DEET release and skin retention significantly. No embryotoxicity observed below 325 mg L−1 in zebrafish model.
Gessyka Rayana Silva Pereira +10 more
wiley +1 more source
Evaluation of an open formula reference diet on California yellowtail (Seriola dorsalis) Broodstock
Abstract The reliable production of marine finfish is contingent on the quantity and quality of the eggs available from the broodstock. Proper broodstock nutrition is critical for maintaining a supply of good quality eggs. Here, we compared an open‐formula reference diet (OFRD; 18 mm pellet) and a commercial broodstock diet (Europa, Skretting; 12 mm ...
Kevin Stuart +2 more
wiley +1 more source

