Results 121 to 130 of about 13,535,371 (355)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Comparison between young males and females with acute myocardial infarction
Arquivos Brasileiros de Cardiologia, 2002 OBJECTIVE: To assess the differences between young males and females after acute myocardial infarction. METHODS: We retrospectively studied 236 patients (54 females and 182 males) after acute myocardial infarction and during hospital stay assessed the ...
Ricardo Augusto Slaibi Conti +5 more
doaj +1 more source
Research report: Exploring the beliefs, attitudes, and behaviors of MSM engaged in substance use and transactional sex in Ghana [PDF]
, 2013 This study was implemented by Boston University in collaboration with the Kwame Nkrumah University of Science and Technology with support from the President’s Emergency Plan for AIDS Relief (PEPFAR) through the U.S.
Adu‐Sarkodie, Yaw +11 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Connexions ‘Active Involvement’ agenda and integrated working [PDF]
, 2009 This research explores the links between Connexions ‘Active Involvement’ agenda and integrated working, and focuses upon local examples and interviews from Coventry and Warwickshire. Connexions One Stop Shops are taken as a particular focus of the report.
Benington, Kris
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
, 1989 This working paper is a draft of the first three chapters of a biography of Thomas, 5th Baron, 1st Earl, and 1st Marquess of Wharton (1648-1715). It traces the development of young Thomas (Tom to his family and eventually to the political world of ...
Clark, J. Kent
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Supporting Young Fathers [PDF]
, 2008 This guide explores how professionals who work with young fathers can help them to be there for their new families by first helping them to develop as individuals.
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