Results 61 to 70 of about 6,717,942 (295)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Place-based approaches to improve the mental health and wellbeing of children and young people: a rapid realist review

Systematic Reviews
Background Adolescent mental health continues to be a pressing public health concern across the globe, in spite of renewed efforts in recent years to improve mental health and wellbeing outcomes.
Anna March, Kate Allen, Karuna Davies, Julie Harris, Alison Bethel, Laura Kennedy, Tamanna Malhotra, Rachael Stemp, Bianca Alexandrescu, Tim Hobbs, Peter Fonagy, Steve Pilling, Vashti Berry   +12 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Reflections on and recommendations from the OCEANIC study CYP and parent advisory group: a Patient and Public Involvement and Engagement case study

Research Involvement and Engagement
Background Patient and Public Involvement and Engagement (PPIE) is increasingly recognised as essential to the relevance, feasibility, and impact of paediatric intensive/critical care research.
Emma Popejoy, Julie Menzies, Aysha Sheikhi, Sally O’Loughlin, Fred O’Loughlin, Deborah Barker, Rachael White, Jos M. Latour, Elizabeth S. Draper, Philip Quinlan, Jane Coad, Joseph C. Manning   +11 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

NSW strategic plan for children and young people – consultation results

, 2016
More than 4,000 children and young people take part in consultations to tell the NSW Government what is or is not working for them. Introduction Every process has a beginning and this report sets out, in detail, the beginning of the development of the ...
Advocate for Children and Young People (NSW)
core  

THE PECULIARITIES OF CARRYING OUT SWIMMING TRAINING AMONG CHILDREN WITH MENTAL RETARDATION OF 11-12 YEARS OLD

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2016
For several years the problem of increasing the effectiveness of training and swimming in children with mental retardation is in the focus of scientific research (T.V. Ermilova, 2012; T.A. Protchenko, 2007; E.S. Zhukova, 2012; B.A. Aikin, 2010 and others.
Mikhail Valerevich Budarin, Aleksander Yurevich Keyno   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source