Results 71 to 80 of about 6,717,942 (295)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Playing it safe? a study of the regulation of outdoor play for children and young people in residential care [PDF]

, 2007
The aim of the research was to describe and explain the barriers to, and opportunities for, outdoor play and recreation that exist in residential child care services.
Milligan, I.M., McGuinness, L., Stevens, I.   +2 more
core   +4 more sources

PREPARATION OF SWIMMING SPECIALISTS ACCORDING TO THE REQUIREMENTS OF MODERN STANDARDS OF SPORT PREPARATION FOR WORK WITH CHILDREN WHO HAVE INTELLECTUAL DISABILITY

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2016
So much attention is paid to sports individuals with intellectual disabilities in international social practice due to at least two factors. Firstly, it is the huge potential of adaptive sport as area of rehabilitation, social integration and improvement
Mikhail Valerevich Budarin, Aleksander Yurevich Keyno   +1 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The impact of living in regional and remote areas on the wellbeing of WA children and young people

, 2015
In 2012 around 27 per cent (27.1%) of all children and young people lived in regional and remote areas of WA. Around 60 per cent (61.6%) of Aboriginal children and young people 0 to 19 years live in regional and remote areas.
Commissioner for Children and Young People (WA)
core  

FLYER: Ethics, Consent and Participation in Research With Children and Young People

, 2013
  Date: Friday, 14 June 2013   Time:10:30 – 13.30 Location: G13, Western Gateway Building, University College Cork The children\u27s Research Network for Ireland and Northern Ireland in conjunction with the Children and Young People Research ...
Children's Research Network
core   +1 more source

THE PROVISION OF ORGANIZATIONAL-METHODICAL CONDITIONS FOR CHILDREN WITH INTELLECTUAL DISABILITY

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2016
Adaptive sport has a multi function focus on all-round development of the personality of the person with disabilities, provides a solution corrective, compensatory and wellness objectives to overcome the defects of physical development, compensation ...
Mikhail Valerevich Budarin, Aleksander Yurevich Keyno   +1 more
doaj   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Exploring the rewards and challenges of paediatric palliative care work – a qualitative study of a multi-disciplinary children’s hospice care team

BMC Palliative Care, 2017
Background Children’s hospices are a key provider of palliative care for children and young people with life-limiting and life-threatening conditions.
Johanna Taylor, Jan Aldridge
doaj   +1 more source