Results 101 to 110 of about 4,196,526 (247)

Massive star clusters detected by JWST as natural birthplaces of intermediate-mass black holes

Astronomy & Astrophysics
The James Webb Space Telescope (JWST) has detected, through gravitational lensing, several young massive star clusters (YMCs), which are considered as relevant building blocks of high-redshift galaxies. In this work, we show how a significant fraction of
Schleicher Dominik R. G., Liempi Matías, Giersz Mirek, Vergara Marcelo C., Flammini Dotti Francesco, Solar Paulo, Escala Andrés, Latif Muhammad A., Reinoso Bastián, Askar Abbas, Schneider Raffaella, Capuzzo-Dolcetta Roberto, Saavedra-Bastidas Jorge, Cuevas Fernando   +13 more
doaj   +1 more source

No evidence of mass segregation in massive young clusters

, 2009
Aims. We investigate the validity of the mass segregation indicators commonly used in analysing young stellar clusters. Methods. We simulate observations by constructing synthetic seeing-limited images of a 1000 massive clusters (104 $M_\odot$)
M. T. V. T. Lago, J. Alves, J. Ascenso
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Clusters, Clumps, Dust, and Gas (CCDG) in NGC 1614: Benchmarking Cluster Demographics in Extreme Systems

The Astronomical Journal
Observations of young star clusters in a variety of galaxies have been used to constrain basic properties related to star formation, such as the fraction of stars found in clusters (Γ) and the shape of the cluster mass function (CMF).
Miranda Caputo, Rupali Chandar, Angus Mok, Sean Linden, Paul Goudfrooij, Bradley C. Whitmore   +5 more
doaj   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Very-high-energy γ-Ray Emission from Young Massive Star Clusters in the Large Magellanic Cloud

The Astrophysical Journal Letters
The Tarantula Nebula in the Large Magellanic Cloud is known for its high star formation activity. At its center lies the young massive star cluster R136, providing a significant amount of the energy that makes the nebula shine so brightly at many ...
F. Aharonian, F. Ait Benkhali, J. Aschersleben, H. Ashkar, M. Backes, V. Barbosa Martins, R. Batzofin, Y. Becherini, D. Berge, K. Bernlöhr, M. Böttcher, J. Bolmont, M. de Bony de Lavergne, J. Borowska, R. Brose, A. Brown, F. Brun, B. Bruno, C. Burger-Scheidlin, S. Casanova, J. Celic, M. Cerruti, T. Chand, S. Chandra, A. Chen, J. Chibueze, O. Chibueze, G. Cotter, P. Cristofari, J. Devin, A. Djannati-Ataï, J. Djuvsland, A. Dmytriiev, K. Egberts, S. Einecke, K. Feijen, M. Filipovic, G. Fontaine, S. Funk, S. Gabici, Y. A. Gallant, J. F. Glicenstein, J. Glombitza, G. Grolleron, L. Haerer, B. Heß, J. A. Hinton, W. Hofmann, T. L. Holch, D. Horns, Zhiqiu Huang, M. Jamrozy, F. Jankowsky, I. Jung-Richardt, E. Kasai, K. Katarzyński, R. Khatoon, B. Khélifi, W. Kluźniak, Nu. Komin, K. Kosack, D. Kostunin, A. Kundu, R. G. Lang, S. Le Stum, A. Lemière, M. Lemoine-Goumard, J.-P. Lenain, F. Leuschner, J. Mackey, V. Marandon, G. Martí-Devesa, R. Marx, A. Mehta, A. Mitchell, R. Moderski, M. O. Moghadam, L. Mohrmann, A. Montanari, E. Moulin, M. de Naurois, J. Niemiec, S. Ohm, L. Olivera-Nieto, E. de Ona Wilhelmi, M. Ostrowski, S. Panny, U. Pensec, G. Peron, G. Pühlhofer, A. Quirrenbach, S. Ravikularaman, M. Regeard, A. Reimer, O. Reimer, H. Ren, M. Renaud, B. Reville, F. Rieger, G. Rowell, B. Rudak, E. Ruiz-Velasco, K. Sabri, V. Sahakian, H. Salzmann, A. Santangelo, M. Sasaki, J. Schäfer, F. Schüssler, H. M. Schutte, H. Sol, S. Spencer, Ł. Stawarz, S. Steinmassl, C. Steppa, K. Streil, I. Sushch, A. M. Taylor, R. Terrier, M. Tsirou, N. Tsuji, C. van Eldik, M. Vecchi, C. Venter, J. Vink, S. J. Wagner, R. White, A. Wierzcholska, M. Zacharias, A. A. Zdziarski, A. Zech, N. Żywucka, H.E.S.S. Collaboration   +132 more
doaj   +1 more source

Multifunctional Ionic Liquid Enabling Cation Homogenization and Lead Chelation for Pure‐Iodide Wide‐Bandgap Perovskite Solar Cells

Advanced Science, EarlyView.
This work presents a multifunctional ionic liquid, [SO3H‐PMIm][OTf], that addresses A‐site cation inhomogeneity and lead toxicity in pure‐iodide wide‐bandgap perovskite solar cells. The additive enables homogeneous cation distribution, achieving 22.02% efficiency with 90% retention after 3000 h and reducing lead leakage by over 58%, thereby ...
Kai Wu, Lei Yang, Guoqing Du, Xin Wang, Jiali Wei, Tiantian Li, Pengfei Zhang, Xiaodan Zhang, Fuhua Hou   +8 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Multiwavelength study of the Carina–Sagittarius Arm

Astronomy & Astrophysics
Aims. Our main goal is to determine whether the lower stellar density observed in the Carina–Sagittarius Arm region (320° ≤ l ≤ 325°, |b| ≤ 1°) is an intrinsic structural feature of the spiral arm or a consequence of high interstellar reddening and ...
Corti M. A., Rizzo L., Paíz L. G., Elizalde Caviglia G. S.   +3 more
doaj   +1 more source